UCHL5
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Official Full Name
ubiquitin carboxyl-terminal hydrolase L5
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Overview
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) belongs to the peptidase C12 family. This protein is protease that specifically cleaves Lys-48-linked polyubiquitin chains, and deubiquitinating enzyme associated with the 19S regulatory subunit -
Synonyms
UCHL5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI 70; INO80 complex subunit R; INO80R; UCH37; ubiquitin thioesterase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; CG;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- SUMO
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UCHL5 Related Articles
- UCHL5 Related Research Area
UCHL5 involved in several pathways and played different roles in them. We selected most pathways UCHL5 participated on our site, such as Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Downregulation of TGF-beta receptor signaling | STUB1;USP15;SMAD3B;PMEPA1;UCHL5;STRAP |
| Signal Transduction | GPR55;ARHGAP36;CGNB;CCNT2B;DHRS4;NPS;GPR77;PROKR1;OXTRL |
| Signaling by TGF-beta Receptor Complex | NEDD8L;USP9;STRAP;PMEPA1;SKILB;NEDD8;CGNB;USP15;TRIM33 |
| TGF-beta receptor signaling activates SMADs | STRAP;PMEPA1;USP15;NEDD8;NEDD8L;UCHL5 |
UCHL5 has several biochemical functions, for example, endopeptidase inhibitor activity, omega peptidase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL5 itself. We selected most functions UCHL5 had, and list some proteins which have the same functions with UCHL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | Serpina1b;SERPINA1A;CAST;CST14B.1;SERPIND1;C4A;SPINT2;C3A.3;SPINK1 |
| omega peptidase activity | USP13;ATXN3;JOSD2;JOSD1;UCHL1;UCHL5;APEH;USP5;ATXN3L |
| poly(A) RNA binding | RPS8;CSDA;RPL31;CSTF3;TAF15;CDC40;PEBP1;RPL5B;EBI3 |
| proteasome binding | USP14;UCHL5;ID1;PSMF1;UBD;PSMG1;PSMD14;USP13;ADRM1 |
| protein binding | VPS8;ZNF576;TJAP1;ANKS1A;RPP25;POLR1B;RPL30;ETV5;SMARCD1 |
| ubiquitin-specific protease activity | USP2;USP42;CYLD;OTULIN;USP45;OTUD7B;IWS1;USP17L5;USP10 |
UCHL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL5.
ADRM1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of UCHL5 protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of UCHL5 protein in organisms and its effects on biological processes.
UCHL5 protein may be highly expressed in specific tissues and cells and low in other tissues and cells. Its expression pattern can be influenced by a variety of factors, including gene regulation, transcription factors, and/or signal transduction pathways.
Mutations or modifications of the UCHL5 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.
This protein may be involved in a variety of biological processes, including protein quality control, cell cycle regulation, DNA repair, and signal transduction. These processes often require the involvement of UPS to achieve protein degradation and regulation.
UCHL5 proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of the UCHL5 protein in cells.
The main function of UCHL5 protein may be as a component of the ubiquitin-proteasome system (UPS), which is involved in the regulation of protein quality control, cell cycle regulation, DNA repair, and signal transduction. It may perform these functions by hydrolyzing specific substrates.
Customer Reviews (3)
Write a reviewThe reproducibility is very good and I get consistent results every time, which makes me feel more confident in the results.
The activity of UCHL5 is maintained for a long time, which ensures the stability of the experimental results.
Excellent performance in Western blot, avoiding interference problems in experiments.
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