ucp1
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  • Official Full Name
  • uncoupling protein 1 (mitochondrial, proton carrier)
  • Background
  • Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
  • Synonyms
  • UCP1; uncoupling protein 1 (mitochondrial, proton carrier); UCP; mitochondrial brown fat uncoupling protein 1; SLC25A7; mitochondrial brown fat uncoupling protein; Solute carrier family 25 member 7; Thermogenin; UCP 1; UCP1_HUMAN; Uncoupling protein 1; OTTHUMP00000164611
Cat.#:UCP1-1552HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human UCP1 Protein (2-307 aa), His-tagged
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Cat.#:UCP1-846HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCP1 Protein (2-307 aa), His-SUMO-tagged
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Cat.#:Ucp1-281MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ucp1 Protein, His-tagged
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Cat.#:Ucp1-283RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ucp1 Protein, His/GST-tagged
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Cat.#:UCP1-46HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human UCP1 protein, GST-tagged
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Cat.#:UCP1-9176HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCP1, His-tagged
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Cat.#:UCP1-12MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse UCP1 protein, His-tagged
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Cat.#:UCP1-17789MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UCP1 Protein
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Cat.#:UCP1-20MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ucp1 protein, His-tagged
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Cat.#:UCP1-27RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat UCP1 protein, His-tagged
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Cat.#:UCP1-28RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat UCP1 protein, His/GST-tagged
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Cat.#:UCP1-6421RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UCP1 Protein
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Cat.#:UCP1-9931ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UCP1
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Cat.#:UCP1-526HCLTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human UCP1 293 Cell Lysate, Flag-tagged
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Involved Pathway

UCP1 involved in several pathways and played different roles in them. We selected most pathways UCP1 participated on our site, such as PPAR signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
ACAA1; PPARDB; SLC27A5; ACOX1; SCD5; CYP4A10; SCP2; FABP2; PPARD; PPARAB
Huntingtons disease
COX7A2; TFAM; RCOR1; ATP5D; NDUFV3; NDUFB6; MT-ATP6; NDUFB10; UQCRC2; UQCRB

Protein Function

UCP1 has several biochemical functions, for example, oxidative phosphorylation uncoupler activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP1 itself. We selected most functions UCP1 had, and list some proteins which have the same functions with UCP1. You can find most of the proteins on our site.
Function
Related Protein
Function oxidative phosphorylation uncoupler activity
Related Protein UCP1; UCP3

UCP1 Related Articles

Brestoff, JR; Kim, BS; et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. NATURE 519:242-+(2015).
Maimaitiyiming, H; Norman, H; et al. CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity. SCIENTIFIC REPORTS 5:-(2015).