VCAN
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Official Full Name
versican
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Overview
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] -
Synonyms
VCAN; versican; WGN; ERVR; GHAP; PG-M; WGN1; CSPG2; versican core protein; versican proteoglycan; large fibroblast proteoglycan; glial hyaluronate-binding protein; chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- His|Myc
- His|T7
- B2M
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- VCAN Related Articles
- VCAN Related Research Area
VCAN involved in several pathways and played different roles in them. We selected most pathways VCAN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with VCAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | B3GAT2;NCAN;GPC1B;VCANB;BGNB;GPC5;CSPG4;BGNA;DCN |
| CS/DS degradation | BGNB;BGN;CSPG5B;BCAN;VCANB;CSPG5;DCN;BGNA;CSPG4 |
| Cell adhesion molecules (CAMs) | PVR;HLA-DPA1;CD4;CLDN23;CD22;BLB1;CLDN15A;VTCN1;CTLA4 |
| Chondroitin sulfate biosynthesis | B3GAT2;VCAN;BGNB;BGNA;CSPG4;VCANB;BGN;BCAN;CSPG5 |
| Chondroitin sulfate/dermatan sulfate metabolism | GPC5;CSPG4;BCAN;CSPG5B;GPC1B;VCANB;BGNB;B3GAT2;NCAN |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | AGRN;VCAN;NCAN;CSPG5;BGN;BCAN;GPC5;GPC6;DCN |
| Defective B3GAT3 causes JDSSDHD | DCN;CSPG5;CSPG4;NCAN;VCAN;BCAN;BGN;GPC5;GPC6 |
| Defective B4GALT7 causes EDS, progeroid type | GPC6;BCAN;BGN;GPC5;CSPG4;DCN;AGRN;VCAN;NCAN |
VCAN has several biochemical functions, for example, calcium ion binding, carbohydrate binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VCAN itself. We selected most functions VCAN had, and list some proteins which have the same functions with VCAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CAPN9;S100A5;ICN2;CALR3B;SLC25A25B;SYT1B;C2CD4B;S100A2;ITIH1 |
| carbohydrate binding | CD209B;ZG16;HBL3;ASGR2;CD209C;MAN2C1;Cd24a;KLRC3;CHODL |
| glycosaminoglycan binding | BGN;PODXL2;SERPINE2;TGFBR3;NDNF;VCAN;TGFBR2;Shh;ENG |
| hyaluronic acid binding | ACAN;LYVE1;VCANB;HYAL2;C1QBP;HAPLN4;IMPG2;HAPLN1A;CD44 |
| protein binding | SSR1;TRPM8;PYGO2;PRELID1;FBXL5;TMED2;OGN;GPR128;CSF3R |
| protein phosphatase binding | MAP3K5;CDKN1B;PPP1R3G;VCAN;CDH5;AP3B1;TRAF3;ANAPC5;CDH2 |
VCAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCAN here. Most of them are supplied by our site. Hope this information will be useful for your research of VCAN.
MMP9; SRGN; cabc1_provu; q9wmx2-pro_0000037548; HSFX2
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