Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

VCP

  • Official Full Name

    valosin containing protein

  • Overview

    Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its
  • Synonyms

    VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VCP-3656H Recombinant Human VCP, GST-tagged E.coli GST C-term-300aa
Human VCP-7934H Recombinant Human VCP protein, His & T7-tagged E.coli His/T7 Gly125~Ile371 (Accession # P55072)
Human VCP-506H Recombinant Human VCP protein, MYC/DDK-tagged HEK293 Myc/DDK
Human VCP-195H Recombinant Human VCP Protein, GST-tagged Insect cell GST
Human VCP-419HCL Recombinant Human VCP 293 Cell Lysate HEK293 N/A
Human VCP-6354H Recombinant Human VCP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VCP-9955HFL Recombinant Full Length Human VCP protein, Flag-tagged Mamanlian cells Flag
Human VCP-6551H Recombinant Human VCP Protein (Gly125-Ile371), N-His tagged E.coli N-His Gly125-Ile371
Mouse VCP-17998M Recombinant Mouse VCP Protein Mammalian Cell His
Mouse VCP-10004M Recombinant Mouse VCP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Vcp-6911M Recombinant Mouse Vcp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Vcp-6834M Recombinant Mouse Vcp Protein (Met1-Gly806), N-His tagged E.coli N-His Met1-Gly806
Mouse VCP-10004M-B Recombinant Mouse VCP Protein Pre-coupled Magnetic Beads HEK293
Rat VCP-6508R Recombinant Rat VCP Protein Mammalian Cell His
Rat VCP-6164R Recombinant Rat VCP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VCP-6164R-B Recombinant Rat VCP Protein Pre-coupled Magnetic Beads HEK293
Zebrafish VCP-11527Z Recombinant Zebrafish VCP Mammalian Cell His
Chicken VCP-3456C Recombinant Chicken VCP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VCP Related Articles
  • VCP Related Research Area

VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumHSPA2;SAR1A;SEC61A1;CALR;SEC61G;CUL1;CCDC102A;CAPN2;XBP1
LegionellosisNAIP1;NFKBIA;ITGAM;MYD88;C3;CXCL1;CLK1;HSPA2;IL12A

VCP has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.

Function Related Protein
ADP bindingAPAF1;GCLC;MYH10;MYH9;MYO9B;PKM;ADCK3;P2RY1;MYO7A
ATP bindingCAMK1GA;DDX50;ABCB3L1;TRIO;ADK;NOL9;PDIK1L;ORC4L;TAOK3
ATPase activityATAD2B;RNF213;NSFA;MYH7;KIF13B;ABCB4;VPS4A;MLH1;ATAD2
BAT3 complex bindingAMFR;VCP;USP13;SGTA
K48-linked polyubiquitin bindingUFD1L;IKBKE;UBXN1;VCP
MHC class I protein bindingTUBB4B;CD8A;CD244;TUBB;VCP;HLA-E;PILRB;DERL1;Pilrb1
deubiquitinase activator activity
identical protein bindingSEPHS1;GRASP;HAPLN2;PIP4K2C;AGXT2;LYZ;EPHA4;CLDNG;PAK2
lipid bindingAPODA.2;APOL2;CRABP2A;FABP7;FABP12;LPAR4;PTGS2;CRABP1B;APOH
poly(A) RNA bindingRPS3A;ADAR;DDX56;AGO3;DDX6;Api5;RBM3;IFI203;CAST
polyubiquitin bindingUBQLN4;DNAJB2;HDAC6;TNIP2;SHARPIN;UBQLN1;RAD23B;EPS15;AGL
protein bindingLNX2B;VEGFAB;DNER;RGR;SFTPD;RAET1D;PSMC4;SETBP1;CBFA2T2
protein domain specific bindingSLC34A2;HMGB2;SCAF1;MECP2;Ar;CNTLN;NEDD4;STX1A;EZR
protein phosphatase bindingGNB2L1;JUPA;PIK3R2;MAP2K7;IRS2;STAT3;PPP1R3C;RPA2;DLG3
ubiquitin protein ligase bindingCUL2;SUMO1;UQCRC1;DAXX;TRIB3;BLZF1;DBT;AXIN2;FZD5
ubiquitin-like protein ligase bindingDDRGK1;TRIP4;VCP;USP13;CDK5RAP3;CEBPB
ubiquitin-specific protease bindingVCP;AMFR;PARK2;SYVN1;MARCH6;BAG6;DERL1;VPS24;PARK7

VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.

ATXN3; NSFL1C; UBXN6

Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can abnormalities in the VCP protein be detected through genetic testing? 10/10/2022

Yes, genetic testing can identify mutations in the VCP gene, aiding in the diagnosis of VCP-related disorders.

Can VCP protein levels be used as a diagnostic marker for specific diseases? 07/28/2021

Currently, VCP protein levels are not widely used as a diagnostic marker, but ongoing research may reveal its potential utility in the future.

Is the VCP protein a potential target for drug development? 01/08/2020

The potential therapeutic targeting of VCP is an area of active research, with efforts to develop drugs that modulate its activity for the treatment of specific diseases.

Can changes in the VCP protein be indicative of other health conditions besides neurodegenerative diseases and cancer? 06/30/2017

Yes, alterations in VCP function may contribute to various health conditions, including autoimmune diseases and metabolic disorders.

How does the VCP protein relate to cellular protein quality control? 03/28/2016

VCP plays a crucial role in eliminating misfolded or damaged proteins, contributing to cellular protein quality control mechanisms.

Customer Reviews (3)

Write a review
Reviews
08/19/2022

    This can involve organizing conferences, workshops, and webinars to discuss the latest advancements, share research findings, and broaden the understanding of VCP function.

    01/30/2022

      Researchers have successfully utilized VCP protein in electron microscopy studies, unraveling crucial insights into protein interactions and conformational changes.

      04/23/2019

        The exceptional performance of VCP protein in both ELISA and protein electron microscopy structure analysis positions it as a valuable tool in a broad range of research applications.

        Ask a Question for All VCP Products

        Required fields are marked with *

        My Review for All VCP Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends