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VRK1

  • Official Full Name

    vaccinia related kinase 1

  • Overview

    The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3). The VRK1 has autophosphorylation activity and phosphorylates several trans
  • Synonyms

    VRK1; vaccinia related kinase 1; serine/threonine-protein kinase VRK1; vaccinia-related kinase 1; vaccinia virus B1R-related kinase 1; PCH1; MGC117401; MGC138280; MGC142070;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|Myc
  • N/A
  • N
  • FLAG
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VRK1-1508H Active Recombinant Human VRK1, GST-tagged Sf9 Insect Cell GST Full length
Human VRK1-322H Active Recombinant Human VRK1 Protein, His & GST-tagged Insect Cell His/GST
Human VRK1-706H Recombinant Human Vaccinia Related Kinase 1, GST-His Sf9 Insect Cell GST
Human VRK1-1117H Recombinant Human Vaccinia Related Kinase 1, GST-tagged Sf9 Insect Cell GST
Human VRK1-520H Recombinant Human VRK1, Gly & Pro tagged Insect Cell His
Human VRK1-31740TH Recombinant Human VRK1 Protein (Full Length), N-His-tagged E.coli N-His
Human VRK1-112H Recombinant Human VRK1 protein, His-tagged E.coli His 411aa
Human VRK1-001HCL Recombinant Human VRK1 cell lysate Insect Cell N/A
Human VRK1-12H Recombinant Human VRK1 Protein (Full Length), N-His-tagged E.coli N-His Full Length
Human VRK1-9822HF Active Recombinant Full Length Human VRK1 Protein, GST-tagged E.coli GST 1-396
Human VRK1-05H Recombinant Human VRK1 Protein (Full Length), N-FLAG tagged Insect Cell N-FLAG Full Length
Human VRK1-1306H Recombinant Human VRK1 protein(Met1-Lys396) Insect Cells N/A Met1-Lys396
Mouse VRK1-2305M Recombinant Mouse VRK1 Protein (1-440 aa), His-Myc-tagged E.coli His/Myc 1-440 aa
Mouse VRK1-2229M Recombinant Mouse VRK1 Protein (1-140 aa), His-Myc-tagged Yeast His/Myc 1-140 aa
Mouse Vrk1-5795M Recombinant Mouse Vrk1 protein, His&Myc-tagged Yeast His&Myc 1-440aa
Rhesus Macaque VRK1-5176R Recombinant Rhesus monkey VRK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque VRK1-4989R-B Recombinant Rhesus Macaque VRK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VRK1-4989R Recombinant Rhesus Macaque VRK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish VRK1-12562Z Recombinant Zebrafish VRK1 Mammalian Cell His
Chicken VRK1-1624C Recombinant Chicken VRK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VRK1 Related Articles
  • VRK1 Related Research Area

VRK1 involved in several pathways and played different roles in them. We selected most pathways VRK1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with VRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleCDK2;CDCA8;SYCE1;CDC14AB;ESCO1;CEP57;E2F2;YWHAE2;HDAC5
Cell Cycle, MitoticTUBB4B;DHFR;DYNC1I2;PLK4;TMEM188;HIST3H2BB;TMPO;LMNB1;DSN1
Clearance of Nuclear Envelope Membranes from ChromatinVRK2;VRK1;LEMD3;BANF1;TMPO
Initiation of Nuclear Envelope ReformationVRK1;TMPO;LEMD3;VRK2;ANKLE2
M PhaseCTDNEP1B;CENPH;KIF2A;SPC25;ITGB3BP;NEK6;ENSAA;CENPE;USO1
Mitotic AnaphasePMF1;ITGB3BP;NDEL1B;NDEL1;ZWINT;CENPL;NUF2;MIS12;CENPN
Mitotic Metaphase and AnaphaseSKA2;CENPL;SPDL1;ZWILCH;CENPP;LEMD3;NUDC;CDCA5;CDCA8
Mitotic ProphaseCTDNEP1B;ARPP19;CTDNEP1A;ARPP19B;NEK7;MCPH1;VRK2;CNEP1R1;NCAPG2

VRK1 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-S10 specific), histone kinase activity (H3-T3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by VRK1 itself. We selected most functions VRK1 had, and list some proteins which have the same functions with VRK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingP2RY2;TPK1;MLH3;PIP5KL1;DCLK1;BBS12;CAMK2D;MYO10;UBA7
histone kinase activity (H3-S10 specific)VRK1;RPS6KA5;RPS6KA4
histone kinase activity (H3-T3 specific)GSG2;VRK1
nucleosomal histone bindingL3MBTL1;VRK1;UHRF1
protein bindingTRIM16;CARD10;TERF2;ARNTL2;THEMIS2;RAMP3;PTH2R;NBR1;SCARF1
protein kinase activityMOK;HIPK3B;DYRK3;NTRK3A;RNASEL;PRKG1A;PRKAA1;DCLK2;TBRG4
protein kinase bindingGRB7;DUSP3;H2AFY;CDK5RAP2;NSF;TELO2;PPP1CC;CCND2;MAVS
protein serine/threonine kinase activityNEK5;MAP3K9;PIM1;PKZ;ACVR1BA;TLK1B;ACVR1B;MAPK4;CSNK1A1L

VRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VRK1.

atp; N/A; COIL

Kim, W; Lyu, HN; et al. Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer. MOLECULAR PHARMACOLOGY 83:367-376(2013).
Valbuena, A; Lopez-Sanchez, I; et al. Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 465:219-226(2007).
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