vrk1
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  • Official Full Name
  • vaccinia related kinase 1
  • Background
  • The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3). The VRK1 has autophosphorylation activity and phosphorylates several trans
  • Synonyms
  • VRK1; vaccinia related kinase 1; serine/threonine-protein kinase VRK1; vaccinia-related kinase 1; vaccinia virus B1R-related kinase 1; PCH1; MGC117401; MGC138280; MGC142070
Cat.#:VRK1-2229MTag:His|Myc
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse VRK1 Protein (1-140 aa), His-Myc-tagged
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Cat.#:VRK1-2305MTag:His|Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse VRK1 Protein (1-440 aa), His-Myc-tagged
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Cat.#:VRK1-706HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Vaccinia Related Kinase 1, GST-His
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Cat.#:VRK1-112HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human VRK1 protein, His-tagged
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Cat.#:VRK1-31740THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VRK1, His-tagged
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Cat.#:VRK1-322HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human VRK1 Protein, His & GST-tagged
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Cat.#:VRK1-520HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human VRK1, Gly & Pro tagged
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Cat.#:VRK1-5176RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey VRK1 Protein, His-tagged
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Cat.#:VRK1-1624CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VRK1
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Cat.#:VRK1-12562ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VRK1
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Cat.#:VRK1-1117HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Vaccinia Related Kinase 1, GST-tagged
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Cat.#:VRK1-1508HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human VRK1 (Active), GST-tagged
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Cat.#:VRK1-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human VRK1 cell lysate
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Involved Pathway

VRK1 involved in several pathways and played different roles in them. We selected most pathways VRK1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with VRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
CENPL; CEP76; TGFB3; CSNK2A2; TINF2; MASTL; USO1; YWHAB; DYNC1H1; MAD1L1
Cell Cycle, Mitotic
CENPJ; CDK4; MCM10; MAPRE1; DHFR; NEK7; CDK6; GORASP1; CKS1B; CDKN1B
Clearance of Nuclear Envelope Membranes from Chromatin
BANF1; TMPO; VRK2; LEMD3; VRK1
Initiation of Nuclear Envelope Reformation
LEMD3; ANKLE2; VRK1; TMPO; VRK2
M Phase
CENPC1; ZWINT; CTDNEP1B; INCENP; DULLARD; MIS12; CENPL; CENPI; SETA; NUDC
Mitotic Anaphase
SGOL2; CDCA8; ZWINT; NUF2; CENPO; NUDC; NDEL1B; CENPN; B9D2; NDC80
Mitotic Metaphase and Anaphase
WAPAL; PANE1; ITGB3BP; NSL1; SKA2; KNTC1; DSN1; RCC2; SGOL2; SKA1
Mitotic Prophase
NCAPH2; SET; SMC4; SMC2; ARPP19A; NCAPG2; CTDNEP1A; NEK6; NEK9; ENSA

Protein Function

VRK1 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-S10 specific), histone kinase activity (H3-T3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by VRK1 itself. We selected most functions VRK1 had, and list some proteins which have the same functions with VRK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP1A2A; GLUL; VPS4B; LATS2; ATP1A1A.5; G3BP1; TP53RK; DDX51; KIF22; YME1L1
Function histone kinase activity (H3-S10 specific)
Related Protein VRK1; RPS6KA5; RPS6KA4
Function histone kinase activity (H3-T3 specific)
Related Protein VRK1; GSG2
Function nucleosomal histone binding
Related Protein VRK1; L3MBTL1; UHRF1
Function protein binding
Related Protein C21orf2; TRIM63; CORO6; TBX22; MSMB; HAT1; ASUN; ZFP488; TGFBI; RADIL
Function protein kinase activity
Related Protein PDK2; CAMKVB; WEE2; PTK2BB; MAP2K2B; MAP4K1; PAN3; ZNF143B; GRK1A; DYRK1AA
Function protein kinase binding
Related Protein TBC1D14; TSKS; AP1B1; PARP1; FAM83A; NSF; FAF1; MLKL; CDC25C; CRY1
Function protein serine/threonine kinase activity
Related Protein ROCK2B; TAF1; LMTK2; STK10; PAK1; TLK1B; MAPK1; CAMK2G1; ACVR1L; STK4

Interacting Protein

VRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VRK1.
atp; N/A; COIL

VRK1 Related Articles

Kim, W; Lyu, HN; et al. Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer. MOLECULAR PHARMACOLOGY 83:367-376(2013).
Valbuena, A; Lopez-Sanchez, I; et al. Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 465:219-226(2007).