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VRK2

  • Official Full Name

    vaccinia related kinase 2

  • Overview

    This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene.
  • Synonyms

    VRK2; vaccinia related kinase 2; serine/threonine-protein kinase VRK2; 2810003O05Rik; AI447698; EC 2.7.11.1; Serine/threonine protein kinase VRK2; Vaccinia virus B1R related kinase 2; Vaccinia-related kinase 2; VRK 2; VRK2_HUMAN; OTTHUMP00000159702; OTTHUMP00000201223; OTTHUMP00000201224; OTTHUMP00000225744; vaccinia virus B1R-related kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VRK2-31741TH Recombinant Human VRK2 Sf9 Insect Cell N/A 375 amino acids
Human VRK2-1118H Recombinant Human Vaccinia Related Kinase 2, GST-tagged Sf9 Insect Cell GST
Human VRK2-3687H Recombinant Human VRK2, GST-tagged E.coli GST N-term-353aa
Human VRK2-381HCL Recombinant Human VRK2 293 Cell Lysate HEK293 N/A
Human VRK2-574H Recombinant Human VRK2 Protein, His&GST-tagged E.coli N-His&GST Met1-Gln290
Mouse VRK2-18389M Recombinant Mouse VRK2 Protein Mammalian Cell His
Mouse VRK2-10079M Recombinant Mouse VRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Vrk2-575M Recombinant Mouse Vrk2 Protein, His&GST-tagged E.coli N-His&GST Met1-Glu234
Mouse VRK2-10079M-B Recombinant Mouse VRK2 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL12139HF Recombinant Full Length Human Serine/Threonine-Protein Kinase Vrk2(Vrk2) Protein, His-Tagged E.coli expression system His Full Length (1-508)
Mus musculus (Mouse) RFL2515MF Recombinant Full Length Mouse Serine/Threonine-Protein Kinase Vrk2(Vrk2) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Zebrafish VRK2-11387Z Recombinant Zebrafish VRK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VRK2 Related Articles

VRK2 involved in several pathways and played different roles in them. We selected most pathways VRK2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with VRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleSMAD3B;CEP76;CENPK;GOLGA2;CEP57;MIS18BP1;ANAPC1;NEK9;HDAC5
Cell Cycle, MitoticMAPRE1A;BANF1;HAUS2;CDKN1B;TUBB4B;SKA1;CDT1;ARPP19A;ARPP19
Clearance of Nuclear Envelope Membranes from ChromatinVRK1;BANF1;LEMD3;VRK2;TMPO
Initiation of Nuclear Envelope ReformationANKLE2;VRK1;TMPO;LEMD3;VRK2
M PhaseCENPA;GORASP2;CENPN;SPC25;KNTC1;CTDNEP1;ENSAB;CENPE;RCC2
Mitotic AnaphaseANKLE2;PMF1;RCC2;SPDL1;SPC25;NUDC;CDCA8;MLF1IP;SKA2
Mitotic Metaphase and AnaphaseNDEL1A;CENPK;PMF1;NDC80;NUF2;MIS12;LEMD3;INCENP;PANE1
Mitotic ProphaseENSA;MCPH1;ARPP19;SET;NEK6;CTDNEP1A;GORASP2;ENSAA;BLZF1

VRK2 has several biochemical functions, for example, ATP binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VRK2 itself. We selected most functions VRK2 had, and list some proteins which have the same functions with VRK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKACAB;TTK;CLK4;NTRK3;UBE1Y1;RIPK3;PRKAG2;HSPA9;FANCM
protein bindingUSP36;RWDD3;MAK;NPHP3;LRP4;DYNC1H1;CDC42EP1;NCF4;RBM39
protein domain specific bindingSTX1B;ARHGEF4;IKBKG;SORBS2;ABCC2;HIST1H4K;RAN;KCTD13;NEDD4
protein kinase bindingZBTB4;AGAP2;CDKN2C;CDK5RAP3;DVL1;CCNA2;CAV2;PAX6;MS4A2
protein serine/threonine kinase activityMYO3B;CAMK1GB;PRKAA2;PRKCBA;CASK;MASTL;SMOK3A;PRKCA;DSTYK

VRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VRK2.

KSR1; ear_ebvb9; MAP2K1; COIL; Mapk8ip1; MAP3K7; BCL2; CDC42; Ktn1; ILK

Galmiche, MC; Rindisbacher, L; et al. Expression of a functional single chain antibody on the surface of extracellular enveloped vaccinia virus as a step towards selective tumour cell targeting. JOURNAL OF GENERAL VIROLOGY 78:3019-3027(1997).
RAY, MK; CHAKRABORTY, A; et al. CHARACTERISTICS OF THE EUKARYOTIC INITIATION FACTOR-II ASSOCIATED 67-KDA POLYPEPTIDE. BIOCHEMISTRY 32:5151-5159(1993).
ISHIBASHI, T; BOTTARO, DP; et al. EXPRESSION CLONING OF A HUMAN DUAL-SPECIFICITY PHOSPHATASE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89:12170-12174(1992).
FULLER, CM; HOWARD, MB; et al. ANTIBODIES AGAINST THE CYSTIC-FIBROSIS TRANSMEMBRANE REGULATOR. AMERICAN JOURNAL OF PHYSIOLOGY 262:C396-C404(1992).
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