vtn
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  • Official Full Name
  • vitronectin
  • Background
  • Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Vitronectin also known as VTN is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy.
  • Synonyms
  • VTN; VN; V75; VNT; vitronectin; epibolin; S-protein; somatomedin B; OTTHUMP00000163323; complement S-protein; serum spreading factor; serum-spreading factor
Cat.#:VTN-675HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human VTN Protein, His-tagged
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Cat.#:VTN-569HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human VTN Protein, MYC/DDK-tagged
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Cat.#:VTN-062HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human VTN Protein, His-tagged
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Cat.#:VTN-220HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human VTN Protein, His-tagged
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Cat.#:VTN-239HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VTN protein
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Cat.#:VTN-248HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VTN, His-tagged
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Cat.#:VTN-2709HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Vitronectin
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Cat.#:VTN-295HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human VTN
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Cat.#:VTN-31131THTag:
Source (Host):Species:Human
Product nameRecombinant Human VTN
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Cat.#:VTN-891HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human VTN, His tagged
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Cat.#:VTN-892HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human VTN protein
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Cat.#:VTN-95HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VTN/TMSB4X protein
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Cat.#:Vtn-1767MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Vtn protein, His-tagged
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Cat.#:Vtn-4054MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Vtn, His tagged
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Cat.#:Vtn-5769RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Vtn protein, His-tagged
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Cat.#:VTN-6618CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VTN
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Cat.#:VTN-2HTag:N/A
Source (Host):Species:Human
Product nameNative Human monomeric vitronectin, Biotin labeled
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Cat.#:VTN-31735THTag:
Source (Host):Species:Human
Product nameNative Human VTN
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Cat.#:VTN-31736THTag:
Source (Host):Species:Human
Product nameNative Human VTN
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Cat.#:VTN-31737THTag:
Source (Host):Species:Human
Product nameNative Human VTN
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Cat.#:VTN-3HTag:N/A
Source (Host):Species:Human
Product nameNative Human multimeric vitronectin, Biotin labeled
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Cat.#:VTN-5410HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Vitronectin
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Cat.#:Vtn-694MTag:N/A
Source (Host):Mouse plasmaSpecies:Mouse
Product nameNative Mouse Vitronectin
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Cat.#:Vtn -70RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat multimeric vitronectin
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Cat.#:Vtn-683RTag:N/A
Source (Host):Rat plasmaSpecies:Rat
Product nameNative Rat Vitronectin
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Cat.#:VTN -33BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovine multimeric vitronectin
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Cat.#:VTN-384BTag:N/A
Source (Host):Bovine plasmaSpecies:Bovine
Product nameNative Bovine Vitronectin
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Cat.#:VTN -61RTag:N/A
Source (Host):Species:Rabbit
Product nameNative Rabbit multimeric vitronectin
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Cat.#:VTN-386RTag:N/A
Source (Host):Rabbit plasmaSpecies:Rabbit
Product nameNative Rabbit Vitronectin
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Cat.#:VTN -51PTag:N/A
Source (Host):Species:Pig
Product nameNative Porcine multimeric vitronectin
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Cat.#:VTN-385PTag:N/A
Source (Host):Pig plasmaSpecies:Pig
Product nameNative Pig Vitronectin
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Cat.#:VTN-2062MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse VTN cell lysate
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Involved Pathway

VTN involved in several pathways and played different roles in them. We selected most pathways VTN participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
FGF14; TCL1B; RBL2; PIK3CB; TSC1; Il2; NGF; RAC1; MDM2; KLK1B4
Focal adhesion
ITGA3; PTK2AA; PDGFRA; TLN2A; DIAPH1; ITGA6B; BCL2; CCND3; PPP1R12C; VEGFAA
ECM-receptor interaction
ITGB1; COL11A2; HMMR; COMP; COL5A2A; TNN; COL6A2; COL2A1B; LAMB1A; THBS3A
Proteoglycans in cancer
WNT16; PLCG2; ITGAV; PXN; IGF1; FZD6; ROCK2; PPP1R12A; DROSHA; VAV2

Protein Function

VTN has several biochemical functions, for example, extracellular matrix binding, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VTN itself. We selected most functions VTN had, and list some proteins which have the same functions with VTN. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix binding
Related Protein CD248; DMP1; BGN; TGFBI; GPR56; SPOCK2; DCN; ITGAV; ITGA2B; SID4
Function heparin binding
Related Protein RSPO2; APOA5; LTBP2; Itgam&Itgb2; FGF2; CHRD; F11; VTN; NRP1; FGFR4
Function integrin binding
Related Protein ICAM2; Npnt; GPNMB; PXN; ACTN1; FERMT3; THBS1; ESM1; LAMA5; L1CAM
Function polysaccharide binding
Related Protein CLEC18A; ENPP2; GM106; CLEC4G; PRG4B; CD209B; MBL1; VTNB; PRG4A; PRG4
Function protein binding
Related Protein MC1R; OSTB; MTCH1; SYT11; ZNF580; PRH2; FRMD5; PDCD6; FGFBP1; THAP10
Function scavenger receptor activity
Related Protein SCART1; CD5; ABHD1; PRSS7; VTNA; VTNB; TINAGL1; CFI; CXCL16; TINAG

Interacting Protein

VTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VTN here. Most of them are supplied by our site. Hope this information will be useful for your research of VTN.
C1QBP; GOPC; SERPINE1; PASK; ganglioside_gm1; ITGAV; ITGB5; GLUD1; f_hcvh; ADH5

VTN Related Articles

Lee, YS; Ryu, SW; et al. Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer. ONCOLOGY REPORTS 33:1985-1993(2015).
Horner, SM; Wilkins, C; et al. Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking. PLOS ONE 10:-(2015).