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VASP

Official Full Name

VASP vasodilator-stimulated phosphoprotein
Overview

VASP (vasodilator stimulated phosphoprotein) plays an important role in ANF/NO/cGMP Protein kinase and cAMP/cAMP Protein kinase signalling pathways. VASP is expressed in almost all human and animal cell lines; particularly high concentrations are found in thrombocytes, vascular smooth muscle cells and fibroblasts. In cultured cells VASP is associated with focal contacts, cell-cell-contacts, microfilaments and dynamic membrane regions such as the leading edge. In vitro binding data show that VASP binds to profilin, zyxin, vinculin, and the Listeria spp. surface protein ActA. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation.
Synonyms

VASP; vasodilator-stimulated phosphoprotein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	VASP-3500H	Recombinant Human VASP, His-tagged	E.coli	His		Inquiry
Human	VASP-30994TH	Recombinant Human VASP, His-tagged	E.coli	His	343 amino acids	Inquiry
Human	VASP-426HCL	Recombinant Human VASP 293 Cell Lysate	HEK293	N/A		Inquiry
Human	VASP-1570H	Recombinant Human VASP Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	VASP-1409HFL	Recombinant Full Length Human VASP Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	VASP-2332H-B	Recombinant Human VASP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	VASP-2332H	Recombinant Human VASP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	VASP-17986M	Recombinant Mouse VASP Protein	Mammalian Cell	His		Inquiry
Mouse	VASP-9999M-B	Recombinant Mouse VASP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Vasp-6901M	Recombinant Mouse Vasp Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	VASP-9999M	Recombinant Mouse VASP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
VASP Related Research Area

VASP involved in several pathways and played different roles in them. We selected most pathways VASP participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VASP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Rap signaling pathway	INS1;RALB;KIT;Itgam&Itgb2;PIK3R1;CALML5;FGF19;AKT2;GNAI3
cGMP-PKG signaling pathway	PDE3A;RHOA;SLC8A1;CREB3L3;ATP1A2;MEF2A;GATA4;INS1;NPR2
Focal adhesion	THBS1;TNC;COL11A2;ACTN1;PIK3R3A;PTEN;MYLK4;LAMA5;CDC42
Platelet activation	GNAI2;PRKCI;TLN1;RAP1B;PLA2G4F;PLA2G4C;ITGA2B;PLA2G4D;ACTG1
Fc gamma R-mediated phagocytosis	PLA2G4A;VAV3;PLD1;PRKCD;PIK3R1;MARCKSL1;PRKCB;WASF1;DOCK2
Leukocyte transendothelial migration	MYL2;NCF2;VAV3;Itgam&Itgb2;CLDN2;VAV1;NOX3;MYLPF;PRKCB

VASP has several biochemical functions, for example, SH3 domain binding, actin binding, profilin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VASP itself. We selected most functions VASP had, and list some proteins which have the same functions with VASP. You can find most of the proteins on our site.

Function	Related Protein
SH3 domain binding	RAD9A;MVB12A;CBL;ARHGAP6;ERRFI1;PDE4D;PTTG1;INPPL1B;ENKUR
actin binding	CAPGA;VMHCL;CORO7;ACTN3;STK38L;MARCKSL1;TNNI1;LRRC10;SPATA31
profilin binding	RHOQ;WIPF1;FMNL1;VASP;CTTN;EVL;DIAP1;CYFIP1;HTT
protein binding	Anks6;TRPC2;SLC4A1A;TACR3;NTM;NOP2;TELO2;NDRG4;CDK10

VASP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VASP here. Most of them are supplied by our site. Hope this information will be useful for your research of VASP.

XIRP1; BAIAP2; FGFR1OP; SCGB2A2; ABI2

Platelet Markers