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WARS2

Official Full Name

tryptophanyl tRNA synthetase 2, mitochondrial
Overview

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
Synonyms

WARS2; tryptophanyl tRNA synthetase 2, mitochondrial; tryptophanyl-tRNA synthetase, mitochondrial; TrpRS; tryptophan tRNA ligase 2; mitochondrial; (Mt)TrpRS; Mitochondrial tryptophanyl tRNA synthetase 2; Tryptophanyl tRNA synthetase 2; tryptophan-tRNA ligase; tryptophan--tRNA ligase; tryptophan tRNA ligase 2, mitochondrial;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WARS2-1273H	Recombinant Human WARS2 protein, His & T7-tagged	E.coli	His/T7	Met1~Leu360 (Accession # Q9UGM6)	Inquiry
Human	WARS2-160H	Recombinant Human WARS2 Protein, His-tagged	E.coli	His		Inquiry
Human	WARS2-369HCL	Recombinant Human WARS2 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Wars2-1274M	Recombinant Mouse Wars2 protein, His & T7-tagged	E.coli	His/T7	Met1~Leu360 (Accession # Q9CYK1)	Inquiry
Mouse	WARS2-18425M	Recombinant Mouse WARS2 Protein	Mammalian Cell	His		Inquiry
Mouse	WARS2-10105M	Recombinant Mouse WARS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	WARS2-10105M-B	Recombinant Mouse WARS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	WARS2-2116Z	Recombinant Zebrafish WARS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

WARS2 involved in several pathways and played different roles in them. We selected most pathways WARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, Gene Expression, Mitochondrial tRNA aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aminoacyl-tRNA biosynthesis	MARS;KARS;QRSL1;HARS2;FARSB;EPRS;GARS;PARS2;EARS2
Gene Expression	ZNF215;MANEA;GTF3C5;ZFP30;SAP30BP;WDR4;ZNF664;COX14;WHSC2
Mitochondrial tRNA aminoacylation	WARS2;KARS;FARS2;EARS2
tRNA Aminoacylation	WARS2;AARS;FARSB;FARS2;MADD;EARS2;EEF1E1;DARS;KARS

WARS2 has several biochemical functions, for example, ATP binding, tryptophan-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WARS2 itself. We selected most functions WARS2 had, and list some proteins which have the same functions with WARS2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	HSP70;SBK3;MAPKAPK2;IP6K2;KATNAL1;EIF4A1A;HSPA5;GRK7;TTK
tryptophan-tRNA ligase activity	WARS2;WARS

WARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WARS2.

CLPP