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WASL

  • Official Full Name

    Wiskott-Aldrich syndrome-like

  • Overview

    This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
  • Synonyms

    WASL; Wiskott-Aldrich syndrome-like; NWASP; N-WASP; neural Wiskott-Aldrich syndrome protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WASL-321H Recombinant Human WASL, MYC/DDK-tagged HEK293 Myc/DDK
Human WASL-320H Recombinant Human WASL, GST-tagged Wheat Germ GST
Human WASL-3699H Recombinant Human WASL, His-tagged E.coli His 1-350aa
Human WASL-367HCL Recombinant Human WASL 293 Cell Lysate HEK293 N/A
Human WASL-547HF Recombinant Full Length Human WASL Protein, GST-tagged In Vitro Cell Free System GST 505 amino acids
Human WASL-8985HFL Recombinant Full Length Human WASL, Flag-tagged Mamanlian cells Flag
Mouse Wasl-6966M Recombinant Mouse Wasl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque WASL-5185R Recombinant Rhesus monkey WASL Protein, His-tagged Mammalian Cell His
Rhesus Macaque WASL-4998R-B Recombinant Rhesus Macaque WASL Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque WASL-4998R Recombinant Rhesus Macaque WASL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken WASL-4346C Recombinant Chicken WASL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

WASL involved in several pathways and played different roles in them. We selected most pathways WASL participated on our site, such as Chemokine signaling pathway, Endocytosis, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with WASL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayGNGT2;GM1987;SHC1;NFKB1;Ccl27a;GRK1;CCL4;CCR9;PF4V1
EndocytosisRAB11BA;MVB12BB;EHD4;SNX32;SMAP2;STAMBP;TFR1A;CHMP4A;VPS37A
Adherens junctionFGFR1A;RHOAC;YES1;PTPN1;INSRB;ACTN3;LEF1;FYNA;AASS
Fc gamma R-mediated phagocytosisRAF1;DOCK2;PIK3R3;GAB2;SPHK2;CFL1;PIK3R2;PIP5K1C;ARPC5L
Regulation of actin cytoskeletonDIAP1;MOS;GSN;ITGB2;PIP4K2A;CDC42L;ITGA3B;PIP5K1A;FGF1B
Bacterial invasion of epithelial cellsCLTB;ELMO1;SEPT12;PIK3CD;ACTG1;CBL;DNM2;SEPT9;CDH1
Pathogenic Escherichia coli infectionRHOA;EZR;ARPC5L;NCL;TUBA1C;TUBA4A;CLDN1;TUBB2B;TUBB2A
ShigellosisPFN3;CDC42;MAPK9;ARPC5L;MAPK3;RHOG;IKBKG;U2AF1L4;MAD2L2
Salmonella infectionDYNC2H1;ROCK1;MAPK8;IL1A;MAPK11;KLC4;IL-8;CXCL8B.3;ROCK2B
Choline metabolism in cancerRAC1;TSC1;SLC22A3;SLC44A2;TSC2;WAS;HIF1A;PDGFB;RAF1

WASL has several biochemical functions, for example, GTPase regulator activity, actin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WASL itself. We selected most functions WASL had, and list some proteins which have the same functions with WASL. You can find most of the proteins on our site.

Function Related Protein
GTPase regulator activityGPSM2;WAS;GPSM3;PCP2;TSC1A;TSC1B;TSC1;RIMS1;RGS14A
actin bindingPOF1B;KCNMA1;EPB41L3B;CAPZA2;PFN2L;MYHC4;MYH9A;CAPZA1B;MSRB1
protein bindingFKBP5;TCTE3;CYBA;MTOR;IFITM1;SMC1A;TLX1;CSDC2;USE1

WASL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WASL here. Most of them are supplied by our site. Hope this information will be useful for your research of WASL.

WIPF1; GRB2; CDC42; ACTR3

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