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WFIKKN1

Official Full Name

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Overview

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.
Synonyms

WFIKKN1; WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; C16orf12, chromosome 16 open reading frame 12; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1; RJD2; WFIKKN; C16orf12; Chromosome 16 open reading frame 12; GASP 2; GASP2; Growth and differentiation factor-associated serum protein; hGASP 2; WAP, follistatin/kazal, immunoglobulin, kunitz and netrin; WAP, FS, Ig, KU, and NTR containing protein; GASP-2; hGASP-2; OTTHUMP00000115417; WAP, FS, Ig, KU, and NTR-containing protein; growth and differentiation factor-associated serum protein 2; WAP, follistatin, immunoglobulin, kunitz and;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	WFIKKN1-18540M	Recombinant Mouse WFIKKN1 Protein	Mammalian Cell	His	Inquiry
Mouse	WFIKKN1-10172M	Recombinant Mouse WFIKKN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	WFIKKN1-10172M-B	Recombinant Mouse WFIKKN1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	WFIKKN1-6589R	Recombinant Rat WFIKKN1 Protein	Mammalian Cell	His	Inquiry
Rat	WFIKKN1-6245R-B	Recombinant Rat WFIKKN1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	WFIKKN1-6245R	Recombinant Rat WFIKKN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	WFIKKN1-12769Z	Recombinant Zebrafish WFIKKN1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
WFIKKN1 Related Articles
WFIKKN1 Related Research Area

WFIKKN1 involved in several pathways and played different roles in them. We selected most pathways WFIKKN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WFIKKN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

WFIKKN1 has several biochemical functions, for example, enzyme inhibitor activity, metalloendopeptidase inhibitor activity, peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WFIKKN1 itself. We selected most functions WFIKKN1 had, and list some proteins which have the same functions with WFIKKN1. You can find most of the proteins on our site.

Function	Related Protein
enzyme inhibitor activity	PLN;PRPSAP1;SCG5;ANGPTL3;ATPIF1;FRY;OAZ1A;ATPIF1B;OAZ2B
metalloendopeptidase inhibitor activity	TIMP2;TIMP2A;WFIKKN1;NGF;SPOCK1;TIMP4;RECK;TIMP3;TIMP1
peptidase inhibitor activity	WFDC15A;SPINK3;Cstb;WFIKKN1;MUG2;PTTG2;WFDC13;SERPINB11;SERPINA3K
protein binding	ZFAND2B;DTNBP1;KIFAP3;IFT20;MID1IP1;PCDH18B;HSF2;LUM;ING4
serine-type endopeptidase inhibitor activity	WFDC3;MUG1;SERPINB6B;AGT;A2ML1;A2M;SERPINC1;SERPINB4;ITIH5

WFIKKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFIKKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFIKKN1.

Harris, RA; Tardif, SD; et al. Evolutionary genetics and implications of small size and twinning in callitrichine primates. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:1467-1472(2014).

Szlama, G; Trexler, M; et al. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS JOURNAL 280:3822-3839(2013).

Serine Proteases and Regulators