wibg
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  • Official Full Name
  • within bgcn homolog
  • Background
  • Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
  • Synonyms
  • WIBG; within bgcn homolog (Drosophila); partner of Y14 and mago; PYM; protein wibg homolog; MGC13064
Cat.#:WIBG-2771HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Within Bgcn Homolog (Drosophila), His-tagged
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Cat.#:WIBG-30861THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WIBG, His-tagged
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Cat.#:WIBG-18548MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WIBG Protein
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Cat.#:WIBG-5215RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WIBG Protein, His-tagged
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Cat.#:WIBG-10872ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WIBG
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Cat.#:WIBG-312HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WIBG 293 Cell Lysate
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Involved Pathway

WIBG involved in several pathways and played different roles in them. We selected most pathways WIBG participated on our site, such as RNA transport, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
CASC3; NUP37; EIF3S10; EIF2B3; EEF1A1L2; RPP40; EIF4EBP3L; RPP25; FXR1; DDX20
mRNA surveillance pathway
HBS1L; CPSF1; EIF4A3; FIP1L1B; PPP2R5CB; ETF1A; pab1; WIBG; PPP2R1B; SYMPK

Protein Function

WIBG has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIBG itself. We selected most functions WIBG had, and list some proteins which have the same functions with WIBG. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein HNRNPL; TIA1; WDR6; ZFP346; RPS23; SEC23IP; PPRC1; HSPA9; G3BP1; RPL31
Function protein binding
Related Protein VPS26A; PLEKHG2; DNAJC28; SEPT12; BEX5; RSG1; GRIA1; RAB35; SIAH2; RXFP1
Function ribosome binding
Related Protein RPN2; SEC61B; SBDS; PPP1R2P9; EIF3K; EIF6; C12orf65; ABCF1; EIF2S1A; EFTUD1

Interacting Protein

WIBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIBG here. Most of them are supplied by our site. Hope this information will be useful for your research of WIBG.
RBM8A; MAGOH; b2r9y1_human; icp27_hhv8p