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WIPF2

Official Full Name

WAS/WASL interacting protein family, member 2
Overview

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.
Synonyms

WIPF2; WAS/WASL interacting protein family, member 2; WAS/WASL-interacting protein family member 2; WICH; WIRE; WIP-related protein; WASP-binding protein; WIP- and CR16-homologous protein; WASP-interacting protein-related protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WIPF2-3732H	Recombinant Human WIPF2, His-tagged	E.coli	His	18-176aa	$319 / 25ug
Mouse	WIPF2-18551M	Recombinant Mouse WIPF2 Protein	Mammalian Cell	His		Inquiry
Mouse	WIPF2-10181M	Recombinant Mouse WIPF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	WIPF2-10181M-B	Recombinant Mouse WIPF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

WIPF2 involved in several pathways and played different roles in them. We selected most pathways WIPF2 participated on our site, such as Endocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIPF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	CAPZA3;KITA;WIPF2;ARFGAP1;ARRB2B;WIPF1;SH3GLB2B;CHMP4B;TGFBR1B
Fcgamma receptor (FCGR) dependent phagocytosis	IgG3;ABI1B;ABI1A;NCKIPSD;PLD4;MYO9B;ACTR3;ABI2;WASF2
Immune System	LAIR1;NCKIPSD;NLRC5;SIGLEC9;ARIH2;MKRN1;GBP1;UBE2J2;DDOST
Innate Immune System	CRP;DEFA5;LGALS3;TNIP2;CRCP;LRRFIP1;ABI1B;NOD1;ABI1A
RHO GTPase Effectors	ZWILCH;NCKAP1;RHOC;RCC2;KNTC1;NCKIPSD;ABI1;SPC24;KIF14
RHO GTPases Activate WASPs and WAVEs	WIPF2;NCKIPSD;WASF3;ABI1A;WIPF3;ABI2;ABI1B
Regulation of actin dynamics for phagocytic cup formation	NCKIPSD;MYO1C;ABI1A;WIPF2;ABI1B;MYO9B;WIPF3
Signal Transduction	OR52B4;OBSCN;RGS10;STAM2;DZIP1;UCHL5;KLHL12;CALML4;ABHD6B

WIPF2 has several biochemical functions, for example, actin filament binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIPF2 itself. We selected most functions WIPF2 had, and list some proteins which have the same functions with WIPF2. You can find most of the proteins on our site.

Function	Related Protein
actin filament binding	TTN;TMOD4;FSCN3;MAP1S;CAPZB;PLS1;PLDN;SVILA;SHROOM2
protein binding	FIP1L1;AMY1B;NAPG;RCN1;KRIT1;TUBA3D;LIN28B;AQP1;COMTD1

WIPF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIPF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WIPF2.

GRB2; WWOX; WASL; WAS; lysR18; NCK1