WNK1

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WNK1

Official Full Name WNK lysine deficient protein kinase 1
Background The WNK [with no lysine (K)] family of serine/threonine kinases is characterized by having a cysteine in place of lysine in subdomain II of its kinase activation domain. The lysine necessary for phosphoryl transfer is located in an atypical position in th
Synonyms WNK1; WNK lysine deficient protein kinase 1; hereditary sensory neuropathy, type II , HSN2, PRKWNK1, protein kinase, lysine deficient 1; serine/threonine-protein kinase WNK1; HSAN2; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-de
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WNK1-1119H Recombinant Human WNK Lysine Deficient Protein Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human WNK1-1933HCL Recombinant Human WNK1 cell lysate N/A
    Human WNK1-5099H Recombinant Human WNK1 Protein, GST-tagged Wheat Germ GST
    Human WNK1-589H Recombinant Human WNK1 Protein, His-tagged E.coli His
    Human WNK1-90H Recombinant Human WNK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse WNK1-18560M Recombinant Mouse WNK1 Protein Mammalian Cell His
    Rat WNK1-6597R Recombinant Rat WNK1 Protein Mammalian Cell His

    WNK1 involved in several pathways and played different roles in them. We selected most pathways WNK1 participated on our site, such as EGFR1 Signaling Pathway, Ion channel transport, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EGFR1 Signaling Pathway ERRFI1; GRB7; REPS2; RBBP7; ZNF259; ZPR1; RALBA; GRB14; ZFP259; ELF3
    Ion channel transport MCOLN3; ANO5B; ATP13A5; TRPV3; SCNN1D; UNC79; ANO10A; CLCNKA; SRI; GABRR2A
    Stimuli-sensing channels Ano3; ANO5B; CLCA1; TTYH1; CLCNKA; TRPM1A; TRPM1B; WNK1; ANO8; TRPC4AP
    Transmembrane transport of small molecules SLC30A3; FTH1B; ATP7B; PDZD11; ABCG4B; SLC43A2; TRPM1; ATP11C; SLC31A1; SLC7A3

    WNK1 has several biochemical functions, for example, ATP binding, chloride channel inhibitor activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK1 itself. We selected most functions WNK1 had, and list some proteins which have the same functions with WNK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding KIF2C; EIF2AK3; MOV10B.1; ACTG1; PRKACBB; PRKACAA; CHORDC1; RAD51C; PRKD2; CAMK1GB
    chloride channel inhibitor activity STX7; VTI1B; CFTR; WNK1; STX8; VAMP8; STX1A
    phosphatase binding SH3YL1; PPP1R37; DLG1L; PPP1R18; PPP1R36; TRPC4AP; DYSFIP1; MAPK1; ELFN2; DLG1
    protein binding LY6H; IFT172; CAV3; NFE2L2; PPP2R5A; KIF13B; Itga10&Itgb1; CDK17; COA3; FKBP1B
    protein kinase inhibitor activity CAMK2N1A; SOCS1; SOCS1B; SH3BP5L; SH3BP5; NPM1; SOCS1A; TAOK3; CISHB; SH3BP5B
    protein serine/threonine kinase activity PRKDC; ULK4; DYRK2; PLK3; PKN1B; STK40; DSTYK; PKN1; MINK1; SQSTM1

    WNK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK1.

    PPP1CA; Syt2; OXSR1; ME2; ZNF839; q81y32_bacan; EPB41L2; TULP3; ARAF; PVR; TNFAIP3; SSFA2; HIVEP2; MYH9; ATXN1; YWHAG; YWHAE

    Sato, A; Shibuya, H; et al. WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression. PLOS ONE 8:-(2013).
    Wade, JB; Fang, L; et al. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F1385-F1393(2011).

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