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WRAP53

  • Official Full Name

    WD repeat containing, antisense to TP53

  • Overview

    This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5" untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5" UTR have been found for this gene.
  • Synonyms

    WRAP53; WD repeat containing, antisense to TP53; TCAB1; WDR79; FLJ10385; telomerase Cajal body protein 1; OTTHUMP00000166046; OTTHUMP00000166047; OTTHUMP00000233829; OTTHUMP00000233830; OTTHUMP00000233831; WD repeat domain 79; WD40 protein Wrap53; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53;

  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Recombinant Proteins
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WRAP53-283HCL Recombinant Human WRAP53 293 Cell Lysate HEK293 N/A
Human WRAP53-2362H-B Recombinant Human WRAP53 Protein Pre-coupled Magnetic Beads HEK293
Human WRAP53-2724H Recombinant Human WRAP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WRAP53-1968HFL Recombinant Full Length Human WRAP53 Protein, C-Flag-tagged Mammalian cells Flag
Human WRAP53-3398H Recombinant Human WRAP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WRAP53-6586H Recombinant Human WRAP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WRAP53-2362H Recombinant Human WRAP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WRAP53-18582M Recombinant Mouse WRAP53 Protein Mammalian Cell His
Mouse WRAP53-10204M Recombinant Mouse WRAP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WRAP53-10204M-B Recombinant Mouse WRAP53 Protein Pre-coupled Magnetic Beads HEK293
Mouse Wrap53-7008M Recombinant Mouse Wrap53 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat WRAP53-6601R Recombinant Rat WRAP53 Protein Mammalian Cell His
Rat WRAP53-6257R-B Recombinant Rat WRAP53 Protein Pre-coupled Magnetic Beads HEK293
Rat WRAP53-6257R Recombinant Rat WRAP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque WRAP53-5220R Recombinant Rhesus monkey WRAP53 Protein, His-tagged Mammalian Cell His
Rhesus Macaque WRAP53-5033R Recombinant Rhesus Macaque WRAP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque WRAP53-5033R-B Recombinant Rhesus Macaque WRAP53 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish WRAP53-8112Z Recombinant Zebrafish WRAP53 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WRAP53 Related Articles

WRAP53 involved in several pathways and played different roles in them. We selected most pathways WRAP53 participated on our site, such as Cell Cycle, Chromosome Maintenance, Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with WRAP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleTUBGCP4;E2F6;MCM3;NEK2;MPEG1;CEP78;NEK7;ARF1;KAT5
Chromosome MaintenanceMIS18BP1;DKC1;HJURP;CENPL;CENPK;CENPC1;TINF2;SMARCA5;WRAP53
Extension of TelomeresWRAP53;RUVBL2;DKC1
Telomere Extension By TelomeraseDKC1;WRAP53
Telomere MaintenanceDKC1;WRAP53

WRAP53 has several biochemical functions, for example, RNA binding, protein binding, telomerase RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WRAP53 itself. We selected most functions WRAP53 had, and list some proteins which have the same functions with WRAP53. You can find most of the proteins on our site.

Function Related Protein
RNA bindingRBFOX2;IFIT8;DUSP11;RPL39L;SCAF1;CPEB1B;CLUHA;KHSRP;SRBD1
protein bindingSTAT5A;TMEM123;CHN1;SERPINB1A;COL8A1;SIAH1A;NUP62CL;MYD88;METTL17
telomerase RNA bindingNHP2;PINX1;WRAP53;HNRNPC;NOP10;GAR1;DKC1;HNRNPU;TERT

WRAP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WRAP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of WRAP53.

DKC1; terc_human_rna; TCP1; CCT3; CCT2

Garvin, S; Tiefenbock, K; et al. Nuclear expression of WRAP53 beta is associated with a positive response to radiotherapy and improved overall survival in patients with head and neck squamous cell carcinoma. ORAL ONCOLOGY 51:24-30(2015).
Henriksson, S; Rassoolzadeh, H; et al. The scaffold protein WRAP53 beta orchestrates the ubiquitin response critical for DNA double-strand break repair. GENES & DEVELOPMENT 28:2726-2738(2014).
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