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WRN

  • Official Full Name

    Werner syndrome, RecQ helicase-like

  • Overview

    The RecQ family of DNA and RNA helicases is a family of enzymes that has been shown to be important to genome integrity (1). Members of this family function in several DNA repair processes including double strand break repair, homologous recombination, an
  • Synonyms

    WRN; Werner syndrome, RecQ helicase-like; Werner syndrome; Werner syndrome ATP-dependent helicase; RECQ3; RECQL2; exonuclease WRN; recQ protein-like 2; DNA helicase, RecQ-like type 3; RECQL3; DKFZp686C2056;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Insect Cells
  • Mammalian Cell
  • Sf9 insect cells
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Myc
  • MBP
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WRN-30699TH Recombinant Human WRN Wheat Germ N/A 111 amino acids
Human WRN-1388H Recombinant Human WRN protein, His&Myc-tagged E.coli His&Myc 500-946aa
Human WRN-1389H Recombinant Human WRN Protein(500-946aa), N-His-tagged E.coli His 500-946aa
Human WRN-1387H Recombinant Human WRN Protein(500-946aa), His&MBP-tagged E.coli His/MBP 500-946aa
Human WRN-12H Recombinant Human WRN Protein, 517-1093, N-GST tagged Sf9 insect cells N-GST 517-1093
Human WRN-1390H Recombinant Human WRN Protein(517-1093aa), His-tagged Insect Cells His 517-1093aa
Human WRN-13H Recombinant Human WRN Protein, non-tagged, Asn500-Gln1229 Insect Cells N/A Asn500-Gln1229
Mouse WRN-18584M Recombinant Mouse WRN Protein Mammalian Cell His
Mouse WRN-10206M Recombinant Mouse WRN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WRN-10206M-B Recombinant Mouse WRN Protein Pre-coupled Magnetic Beads HEK293
Chicken WRN-5447C Recombinant Chicken WRN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WRN Related Articles

WRN involved in several pathways and played different roles in them. We selected most pathways WRN participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with WRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Double-Strand Break RepairRAD51AP1;PAXIP1;TDP2B;BRCC3;UBE2V2;KDM4B;EYA3;BRE;THRSP
DNA RepairALKBH3;ZFP830;RAD18;GEN1;MAD2L2;KIAA1530;APITD1;RAD9;USP43A
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)RAD51AP1;FAM175A;EME2;RAD9;TIPIN;TP53BP1;EME1;THRSP;BRE
HDR through Homologous Recombination (HRR)RAD9B;RHNO1;HUS1;GEN1;TOPBP1;RBBP8;KIAA0146;RTEL1;FUZ
HDR through Single Strand Annealing (SSA)WRN;RHNO1;TOPBP1
Homologous DNA Pairing and Strand ExchangeTOPBP1;WRN;RAD51AP1;RHNO1
Homology Directed RepairRTEL1;FUZ;RNF4;KIAA0146;GEN1;EME2;WRN;PPP4R2B;TOPBP1
Integrated Pancreatic Cancer PathwayRAPGEF3;IL11;RB1CC1;GPRC5A;CASP12;JUND;FST;TOP1;LEFTY1

WRN has several biochemical functions, for example, 3-5 DNA helicase activity, 3-5 exonuclease activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WRN itself. We selected most functions WRN had, and list some proteins which have the same functions with WRN. You can find most of the proteins on our site.

Function Related Protein
3-5 DNA helicase activityCDC45;FBXO18;GINS1;WRN;ERCC3
3-5 exonuclease activityMRE11A;EXD2;RAD9;APLF;EXOSC10;POLA1;EXD1;RAD9A;WRN
ATP bindingNPR1A;MASTL;CDK17;PEX1;ACTC1;DGKE;ATP1A1A.4;CCT3;PTK2BB
ATP-dependent 3-5 DNA helicase activityASCC3;RECQL4;BLM;WRN
ATP-dependent DNA helicase activityBLM;XRCC5;CHST13;BRIP1;DDX11;CHD4;RUVBL2;RECQL;ERCC3
ATPase activityVPS4A;MYH8;WRN;KIF21A;ABCA9;ABCA4A;KIF9;OLA1;KIF4
DNA bindingHOXC12B;EGR3;RX3;TSHZ1;MEIS1B;ZNF544;HBP1;ZNF672;HIST1H3G
DNA helicase activityMCM3L;IGHMBP2;PEO1;RAD54B;MCM5;INO80;DNA2;ATRX;PIF1
G-quadruplex DNA bindingDHX36;WRN;BLM;LONP1
Y-form DNA bindingRAD18;MSH3;MSH2;WRN;MEN1
bubble DNA bindingERCC5;WRN;RECQL4;NEIL3;HMGB1;BLM
exonuclease activityMEIOB;XRN1;REXO1L1;TDP1;WRN;EXO1;DOM3Z;CNOT6L;ISG20
four-way junction helicase activityBLM;WRN
helicase activityDICER1;CHD1L;CHD8;SMARCA2;DDX6;EP400;MOV10;DDX58;SMARCA4
magnesium ion bindingNME1;SIK2;LHPP;IMPA2;STK3;MAP2K7;IRAK4;NCS1;PPM1N
manganese ion bindingFAM20C;MTPAP;PPM1AB;ATP2C1;PPEF2;WRN;ABL1;ENDOU;TDP2
protein bindingKCNJ10;BBS1;HCK;ZNF397;HARS2;EIF5B;PSPC1;SEC61B;CNTROB
protein complex bindingTWF1;Ctsl;ATP6V0D1;CRTAP;NDUFA8;GNB1;SH2B3;LCK;RIPK1
protein homodimerization activityXPA;KIAA1804;PCYT1A;FOXP3;BNIP3L;HARS2;WWTR1;NR6A1A;TBX18

WRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WRN here. Most of them are supplied by our site. Hope this information will be useful for your research of WRN.

XRCC5; XRCC6; RPA1

Goto, M; et al. Anti-WRN(RecQ3 DNA/RNA helicase) antibodies in systemic sclerosis.. ARTHRITIS AND RHEUMATISM 52:S368-S369(2005).
Bordi, L; Amendola, A; et al. Expression of Werner and Bloom syndrome genes is differentially regulated by in vitro HIV-1 infection of peripheral blood mononuclear cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 138:251-258(2004).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do genetic mutations in the WRN gene affect its function? 11/22/2022

Mutations in WRN can disrupt its enzymatic activities, leading to genomic instability and disease.

What are the implications of altered WRN activity in aging and age-related diseases? 02/03/2020

Altered WRN activity is associated with accelerated aging and increased risk of age-related diseases.

What role does WRN play in DNA repair and replication? 06/23/2019

WRN plays a crucial role in both DNA repair and replication processes.

How does WRN deficiency lead to Werner syndrome? 06/09/2019

Deficiency in WRN leads to accelerated aging symptoms in Werner syndrome, due to impaired DNA repair.

What potential therapeutic approaches target WRN for treating Werner syndrome and other age-related conditions? 07/21/2018

Therapies targeting WRN aim to enhance DNA repair mechanisms, potentially treating Werner syndrome and related conditions.

How does WRN interact with other proteins in the maintenance of genomic stability? 07/11/2017

WRN cooperates with other proteins to ensure accurate DNA repair and replication.

What is the primary function of WRN in cellular processes? 07/02/2017

WRN is involved in DNA repair and maintenance of genomic stability.

Customer Reviews (3)

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Reviews
10/15/2022

    Supports our research with high-quality data.

    03/15/2021

      Reliable partner for our protein experiments.

      04/03/2017

        Helps us achieve research milestones consistently.

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