Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

XRCC2

Official Full Name

X-ray repair complementing defective repair in Chinese hamster cells 2
Overview

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
Synonyms

XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2; DNA repair protein XRCC2; RAD51 like; X-ray repair cross-complementing protein 2; X-ray repair, complementing defective, repair in Chinese hamster; DKFZp781P0919;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	XRCC2-5013H	Recombinant Human XRCC2, His-tagged	E.coli	His	Inquiry
Human	XRCC2-412H	Recombinant Human X-ray repair complementing defective repair in Chinese hamster cells 2, His-tagged	E.coli	His	Inquiry
Human	XRCC2-257HCL	Recombinant Human XRCC2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	XRCC2-3240H	Recombinant Human XRCC2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	XRCC2-18636M	Recombinant Mouse XRCC2 Protein	Mammalian Cell	His	Inquiry
Mouse	XRCC2-10240M-B	Recombinant Mouse XRCC2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	XRCC2-10240M	Recombinant Mouse XRCC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Xrcc2-7023M	Recombinant Mouse Xrcc2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry

Involved Pathway
Protein Function
Interacting Protein

XRCC2 involved in several pathways and played different roles in them. We selected most pathways XRCC2 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	SHFM1;BLM;XRCC3;POLD4;RAD54L;RAD51D;RAD52;RAD51L3;RAD51L1

XRCC2 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC2 itself. We selected most functions XRCC2 had, and list some proteins which have the same functions with XRCC2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ATP7B;TSSK4;FARSA;CKMT2;WEE1;SRR;EHD1;NME2B.2;EPHA1
DNA-dependent ATPase activity	TTF2;CDK7;SMARCA4;XRCC2;RAD51C;DHX36;ERCC2;SMARCAL1;RAD51L3
double-stranded DNA binding	PIN4;SETMAR;TP63;USF1;KLF6;NKX2-8;TRP63;AFF3;HNRPDL
contributes_to endodeoxyribonuclease activity	RAD51L1;RAD51D;DMC1;RAD51B;ERCC4;RAD51;RAD51L3;XRCC2
contributes_to four-way junction DNA binding	RAD51C;RAD51L1;MSH2;RAD51L3;MSH6;XRCC2;RAD51B;XRCC3;RAD51D
protein binding	CDC5L;NCF2;OPRM1;C11orf49;ETL4;EIF3D;ZNF2;TRIB3;HGS
recombinase activity	XRCC3;RAD51;DMC1;RBPJ;RAD51C;RAD51D;RAD51L3;RAD51L1;RAD51B
single-stranded DNA binding	PURA;RAD51AP1;XRCC3;HSPD1;NCL;PURB;PCBP1;MLH3;ANXA1

XRCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC2.

RAD51D