xrcc6
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  • Official Full Name
  • X-ray repair complementing defective repair in Chinese hamster cells 6
  • Background
  • The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
  • Synonyms
  • XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6; ML8; KU70; TLAA; CTC75; CTCBF; G22P1; X-ray repair cross-complementing protein 6; 5-dRP lyase Ku70; Ku autoantigen, 70kDa; DNA repair protein XRCC6; Ku autoantigen p70 subunit; 70 kDa subunit of Ku antigen; thyroid-lupus autoantigen p70; lupus Ku autoantigen protein p70; 5-deoxyribose-5-phosphate lyase Ku70; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; thyroid autoantigen 70kD (Ku antigen); ATP-dependent DNA helicase 2 subunit 1; thyroid autoantigen 70kDa (Ku antigen); ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit;
Cat.#:XRCC5-149HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human XRCC5 protein, His-tagged
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Cat.#:XRCC6-1548HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC6 protein
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Cat.#:XRCC6-2000HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human XRCC6 protein, His-tagged
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Cat.#:XRCC6-29198THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC6, His-tagged
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Cat.#:XRCC6-31455THTag:His
Source (Host):Species:Human
Product nameRecombinant Human XRCC6, His-tagged
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Cat.#:XRCC6-18640MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse XRCC6 Protein
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Cat.#:Xrcc6-448MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Xrcc6 Protein, His-tagged
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Cat.#:Xrcc6-449RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Xrcc6 Protein, His-tagged
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Cat.#:XRCC6-6488CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken XRCC6
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Cat.#:XRCC6-10274ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish XRCC6
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Cat.#:XRCC5 & XRCC6-543HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human XRCC5 & XRCC6 cell lysate
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Cat.#:XRCC6-253HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human XRCC6 293 Cell Lysate
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Involved Pathway

XRCC6 involved in several pathways and played different roles in them. We selected most pathways XRCC6 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Non-homologous end-joining
LIG4; NHEJ1; DCLRE1C; POLM; XRCC6; XRCC4; POLL; PRKDC; MRE11A; FEN1

Protein Function

XRCC6 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC6 itself. We selected most functions XRCC6 had, and list some proteins which have the same functions with XRCC6. You can find most of the proteins on our site.
Function
Related Protein
Function 5-deoxyribose-5-phosphate lyase activity
Related Protein HMGA2; XRCC6; HMGA1-RS1; HMGA1
Function ATP binding
Related Protein GSG2; ACTB2; MCM8; ACTA2; ORC1L; ABCD3B; ATP13A3; VARS; KSR1; CLPXA
Function ATP-dependent DNA helicase activity
Related Protein GTF2H4; CHST13; BLM; XRCC6; WRN; BRIP1; CHD1; ERCC2; XRCC5; RUVBL2
Function DNA binding
Related Protein RTEL1; HIST1H2BF; THAP10; HIVEP2; CHTF18; VEZF1; SP1; ZNF434; OTX1B; ZNF566
Function damaged DNA binding
Related Protein TP53BP1; BRCA1; XRCC5; POLD1; DCLRE1A; TRPC2; RUVBL2; TP53; APEX1; XPC
Function double-stranded DNA binding
Related Protein TP53; TARDBP; SMAD2; KLF6; MEN1; XRCC5; SATB1; HLF; TP63; RAD51B
Function contributes_to double-stranded telomeric DNA binding
Related Protein XRCC6; XRCC5
Function poly(A) RNA binding
Related Protein ETF1A; GNL3; CCDC47; SEC61B; CCT4; CPEB2; NAP1L4; SF3A2; MRPS30; NCOA5
Function protein C-terminus binding
Related Protein PLEKHB1; MID1IP1; NCL; SHANK2; PEX5; NEIL1; RABAC1; CALCOCO1; PEX1; MIF4GD
Function protein binding
Related Protein BBS13; PRPF4; YIF1A; SAFB2; ITPRIPL1; TMEM203; DARS; CITED2; SHE; TNNI2
Function transcription regulatory region DNA binding
Related Protein GABPB1; SMAD7; DDIT3; PAX8; ARID4A; SERPINB1A; NR1D1; CREB3L2; ZBTB14; ATF4

Interacting Protein

XRCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC6.
XRCC5; PRKDC; WRN