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PTI

  • Official Full Name

    pancreatic trypsin inhibitor

  • Overview

    The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and;ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was;found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic;progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection;against leakage of lysosomal content during stress, and that loss of this protection results in cell death and;sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms

    PTI; pancreatic trypsin inhibitor; Basic protease inhibitor; BPI; BPTI; aprotinin;

  • Native Proteins
  • Recombinant Proteins
  • Therapeutic Proteins
  • Bovine
  • Bovine Lung
  • E.coli
  • Maize
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Bovine PTI-29B Active Native Bovine Aprotinin Bovine Lung N/A
Bovine PTI-50B Recombinant Bovine Pancreatic Trypsin Inhibitor E.coli N/A
Bovine PTI-5357B Recombinant Bovine Pancreatic Trypsin Inhibitor Maize N/A
Bovine PTI-P063B Native Bovine PTI therapeutic protein N/A 58 Aa
Bovine PTI-1900B Native Bovine Pancreatic Trypsin Inhibitor Bovine Lung N/A
Bovine PTI-603B Native Bovine Pancreatic Trypsin Inhibitor Bovine Lung N/A
Bovine PTI-152B Active Recombinant Bovine PTI Protein E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTI Related Articles

PTI involved in several pathways and played different roles in them. We selected most pathways PTI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PTI has several biochemical functions, for example, potassium channel inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTI itself. We selected most functions PTI had, and list some proteins which have the same functions with PTI. You can find most of the proteins on our site.

Function Related Protein
potassium channel inhibitor activityRASA1;PTI;KCNK2;ENSA;NEDD4L;CAV3;KCNA5
protein bindingORAI1;FLT4;MIEN1;FGF19;MYL12B;ANKRA2;FZD10;RGS14;PACSIN3
serine-type endopeptidase inhibitor activityAPLP2;HRG;PCSK1NL;SERPING1;TFPI2;SERPINA10A;TFPIA;ITIH2;SLPI

PTI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTI here. Most of them are supplied by our site. Hope this information will be useful for your research of PTI.

try1_bovin; polg_den26; q52v24_astlp; Prss2; tap_ornmo

Newcomer, BW; Toohey-Kurth, K; et al. Laboratory diagnosis and transmissibility of bovine viral diarrhea virus from a bull with a persistent testicular infection. VETERINARY MICROBIOLOGY 170:246-257(2014).
Leonidova, A; Pierroz, V; et al. Photo-induced uncaging of a specific Re(I) organometallic complex in living cells. CHEMICAL SCIENCE 5:4044-4056(2014).
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