YARS
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Official Full Name
tyrosyl-tRNA synthetase
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Overview
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. -
Synonyms
YARS; tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; tyrosine tRNA ligase 1; cytoplasmic; tyrRS; YRS; YTS; CMTDIC; SYYC_HUMAN; Tyrosyl tRNA synthetase; Tyrosyl--tRNA ligase; OTTHUMP00000004027; tyrosine tRNA ligase 1, cytoplasmic;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
YARS involved in several pathways and played different roles in them. We selected most pathways YARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with YARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | DARS2;WARS;PSTK;FARSB;GATB;GARS;TARSL2;NARS2;EPRS |
YARS has several biochemical functions, for example, ATP binding, interleukin-8 receptor binding, NOT isoleucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by YARS itself. We selected most functions YARS had, and list some proteins which have the same functions with YARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CLK1;CDK6;SCN8A;SRPK1A;PRKCHB;ATP2B3B;LONP1;PAK1;P2RX8 |
| interleukin-8 receptor binding | MADD;YARS;IL-8 |
| NOT isoleucine-tRNA ligase activity | YARS;MADD |
| poly(A) RNA binding | TUFM;ROCK2;RPLP0;DIMT1;LIN28B;SYNE1;HNRNPF;ATP5C1;RPL24 |
| signal transducer activity | ITGB3BP;OLFR13;ILK;VMN1R40;OLFR186;MRGPRB2;FAS;TAS2R137;ADORA2AB |
| tRNA binding | XPO5;MADD;AARS;TYW5;THG1L;PTCD1;KARS;SEPSECS;IFIT5 |
| tyrosine-tRNA ligase activity | MADD;YARS;YARS2 |
YARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YARS here. Most of them are supplied by our site. Hope this information will be useful for your research of YARS.
SAP18; EIF1B; EIF6; GABARAPL2; ARF6; IKBKE; FTSJ1; TRAF6; VCAM1; Wdr5; PPP2R2A; Map3k12; Mib1; Sidt2; Pxdc1; SORT1
- Q&As
- Reviews
Q&As (5)
Ask a questionYARS protein can promote tumor growth and metastasis in certain types of cancer through its role in protein synthesis and cell signaling pathways.
Modifying YARS protein function through small molecules or gene therapy is being explored as a potential therapeutic strategy in disease contexts.
Certain cancer subtypes and neurological disorder patients with YARS protein dysregulation may potentially benefit from targeted therapies, pending further research.
YARS protein dysfunction has been implicated in certain neurological disorders, such as Charcot-Marie-Tooth disease and peripheral neuropathy.
Research suggests that targeting YARS protein may have therapeutic potential in certain cancer types, but further studies are needed to validate this approach.
Customer Reviews (3)
Write a reviewThe manufacturer of the YARS protein plays a vital role in supporting my trials.
the YARS protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.
By using the YARS protein in my experiments, I am confident in obtaining accurate and dependable data.
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