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ZFHX3

Official Full Name

zinc finger homeobox 3
Overview

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
Synonyms

ZFHX3; zinc finger homeobox 3; AT binding transcription factor 1 , ATBF1; zinc finger homeobox protein 3; ZNF927; Alpha fetoprotein enhancer binding protein; AT binding transcription factor 1; AT motif binding factor; ATBT; ZFH-3; OTTHUMP00000174934; AT motif-binding factor 1; AT-binding transcription factor 1; zinc finger homeodomain protein 3; alpha-fetoprotein enhancer binding protein; alpha-fetoprotein enhancer-binding protein; ATBF1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZFHX3-3799H	Recombinant Human ZFHX3, His-tagged	E.coli	His	921-1270aa	$319 / 25ug
Chicken	ZFHX3-5520C	Recombinant Chicken ZFHX3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ZFHX3 Related Articles

ZFHX3 involved in several pathways and played different roles in them. We selected most pathways ZFHX3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZFHX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells	DLX5;FZD9;ACVR1C;REST;WNT8A;MEIS1;WNT7A;ZFHX3;INHBB

ZFHX3 has several biochemical functions, for example, core promoter sequence-specific DNA binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZFHX3 itself. We selected most functions ZFHX3 had, and list some proteins which have the same functions with ZFHX3. You can find most of the proteins on our site.

Function	Related Protein
core promoter sequence-specific DNA binding	THRAP3;CRY1;ZNF750;CHD2;TRP53;ESR1;ZFP932;H2AFY;SOHLH2
enzyme binding	DIS3L;KMT2E;IL6R;PTEN;MLEC;IQCB1;UBE2I;PARP4;TSPAN33
protein binding	BAZ1B;FTCD;INO80;FBXO2;Trf;SPEF2;BCAM;DNA2;HAND2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	HNF1B;ATF2;GTF2IRD1;CIR1;SOX9;PKNOX1;MYOG;FOXC2;ATF1
transcription factor activity, sequence-specific DNA binding	YBX1;NR5A1B;NKX3-1;RFX3;SLC25A46;HOMEZB;KAT7A;ARID4A;FOXP4
transcription regulatory region DNA binding	AIRE;SMAD4;MTERF3;ZFP382;SOX6;SMARCA2;BRD7;CTCFL;TAF2
zinc ion binding	ERAP1;Shh;SP140;TRIM55A;TET1;GDA;ZDHHC20;TIMM13;MAN2C1

ZFHX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZFHX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZFHX3.

ybtE; MYC; WRAP53

Lee, JH; Nam, H; et al. Upregulation of GM-CSF by TGF-beta 1 in epithelial mesenchymal transition of human HERS/ERM cells. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 50:399-405(2014).

Chaudhry, P; Fabi, F; et al. Prostate apoptosis response-4 mediates TGF-beta-induced epithelial-to-mesenchymal transition. CELL DEATH & DISEASE 5:-(2014).