FOS
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Official Full Name
FBJ murine osteosarcoma viral oncogene homolog
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Overview
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] -
Synonyms
FOS; FBJ murine osteosarcoma viral oncogene homolog; p55; AP-1; C-FOS; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293F
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FOS Related Articles
- FOS Related Research Area
- FOS Related Signal Pathway
FOS involved in several pathways and played different roles in them. We selected most pathways FOS participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | IL1R2;MAP4K1;PPM1NB;GRB2A;TRAF2;MAPK12B;Casp3;TAOK2;MKNK2 |
| cAMP signaling pathway | CNGA4;ATP1A1;PTGER2;NPY1R;SOX9;ROCK1;FXYD1;PDE4A;PPARA |
| Osteoclast differentiation | ITGB3;RELA;LILRB1;BTK;FCGR1A;CYLD;TRAF2;TEC;LILRB3 |
| Toll-like receptor signaling pathway | AKT2L;IFNA21;MAPK8A;IRF7;CCL4L1;TLR1LB;CCL3;CASP8;RAC1 |
| T cell receptor signaling pathway | CD28;MUC1;BCL10;GRB2;NFATC2;MAPK11;VAV1;MAP3K7;CD4 |
| B cell receptor signaling pathway | MALT1;GSK3AB;AKT2;MAP2K1;LCP2A;PIK3CA;NFATC2;PTPN6;RELA |
| TNF signaling pathway | LIF;MAP2K7;PIK3R2;CXCL5;MAPK10;MAP2K4;MAPK9;TNF;MAPK11 |
| Circadian entrainment | CALM3;GRIN2B;KCNJ9;GNAI2;PER2;CALM2;GNG5;PRKACG;PRKG1 |
| Cholinergic synapse | PIK3R3;ACHE;CREB3L4;FOS;HRAS;CHRNA4;GNAI1;CHRM1;GNG13 |
| Dopaminergic synapse | SLC6A3;CREB3;PPP2R5B;CREB3L3;GRIA2;CREB3L1;SLC18A2;CREB3L4;GNAI3 |
| Estrogen signaling pathway | CALM3;PLCB3;ITPR3;ESR2;GPR30;CREB3L1;SHC1;PIK3CD;PRKACB |
| Prolactin signaling pathway | SOCS3;CCND2;MAPK3;STAT1;PIK3R5;PRL;TNFRSF11A;MAPK1;STAT5B |
| Oxytocin signaling pathway | GNAI1;TRPM2;CAMK2A;PIK3CB;CAMK2G;ROCK1;NFATC4;GNAQ;PPP3CA |
| Salmonella infection | MAPK11;CCL4;WASLB;LBP;CXCL8B.3;RAC1;PKN2;KLC2;CD14 |
| Pertussis | C3;C1QA;Casp3;Il23a;C1RA;IRAK1;LY96;CD14;MAPK8 |
| Leishmaniasis | TLR2;IRAK4;IFNGR1;MAP3K7;HLA-DPB1;TRAF6;FCGR1;FCGR3A;STAT1 |
| Chagas disease (American trypanosomiasis) | NFKBIA;GNAS;TRAF6;CCL3L1;PLCB4;CALR;TNFRSF1A;CCL2;MAP2K4 |
| Hepatitis B | STAT5B;IFNA2;IRF7;CYCS;PIK3R3;PIK3R5;STAT5A;MYD88;NFATC4 |
| HTLV-I infection | H2-AB1;DLG1;RELB;POLE;CRTC2;WNT5A;GSK3B;IL1R2;TGFB2 |
| Herpes simplex infection | BF2;IFNA14;BMA2;TLR9;EEF1DA;HLA-DQA1;CASP8;CLOCKB;HCFC1 |
| Pathways in cancer | BIRC5;PLD1;GNGT1;FGF18;FZD7;ARAF;PRKCG;FLT3;FGF20 |
| Colorectal cancer | PIK3CG;SMAD2;PIK3R2;RALGDS;TGFB3;Casp3;SMAD3;RAF1;MAPK10 |
| Choline metabolism in cancer | EGF;MAP2K2;GRB2;WASF3;PLCG1;Pdgfa&Pdgfb;PRKCB;PLA2G4B;DGKZ |
| Rheumatoid arthritis | ATP6V0D2;ITGAL;ATP6V1F;ATP6V1D;IL1A;HLA-DRB3;IFNG;ATP6V0E2;ATP6V0B |
FOS has several biochemical functions, for example, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOS itself. We selected most functions FOS had, and list some proteins which have the same functions with FOS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| R-SMAD binding | PMEPA1;RANBP3;MYOCD;ANKRD1;SMAD2;C18orf1;MEN1;ZC3H3;PAX6 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NR4A3;TTC6;MXD1;JUNBB;NOBOX;H2AFZ;GMEB1;MYF5;CEBPA |
| RNA polymerase II core promoter sequence-specific DNA binding | GBX2;ZNF335;TAL1;SOX8;FOS;HEYL;NSD1;H3F3B;H2AFZ |
| chromatin binding | SMAD4;ENY2;SP140;GATA1A;PBRM1;HMGB4;UXT;TLE4;NCAPD2 |
| protein binding | EEF1B2;LACTB2;DPF2;CDCA7L;GPSM1;CIRBP;NOD1;TSKS;CD48 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJB;FOSL1;ARNTL2;IRF7;CREB3;CLOCK;JDP2;SFPI1;FOS |
| transcription factor activity, sequence-specific DNA binding | UBN2;ATF5;TGIF2;POU5F2;ZKSCAN6;POU5F1;FOXN2B;NKX3;FOXO1B |
| transcription factor binding | ARHGEF2;JUND;PBX2;EPAS1;SMARCA4;SP1;DIP2B;PIANP;PURB |
| transcription regulatory region DNA binding | PRDM5;ATF3;TBL1XR1;GRHL2B;RCOR1;XRCC6;RFX6;HHEX;HINFP |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TP73;JUNB;TFE3A;ETV4;GATA3;SMAD1;KCNA3;PPARA;FOXJ2 |
FOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOS here. Most of them are supplied by our site. Hope this information will be useful for your research of FOS.
JUN
- Q&As
- Reviews
Q&As (5)
Ask a questionElevated levels of FOS protein in specific diseases may serve as a prognostic marker, indicating disease severity and progression.
FOS protein plays a crucial role in signaling pathways, providing insights into how cells respond to various stimuli, including stress and growth factors.
FOS protein acts as a transcription factor, regulating the expression of genes involved in cell proliferation, differentiation, and survival.
FOS protein analysis can provide valuable information for tailoring treatment strategies based on the individual's molecular profile, contributing to personalized medicine.
Targeting FOS protein for therapeutic purposes can be challenging due to its involvement in various cellular processes, requiring precise modulation.
Customer Reviews (3)
Write a reviewIts reliability and high quality make it a valuable tool in various applications, ranging from enzymatic assays to studying protein-protein interactions.
The FOS protein is highly regarded for its excellent performance in WB assays and its significant contribution to protein EM structure analysis.
The FOS protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.
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