GNAI1
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Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
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Overview
Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. -
Synonyms
GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1; Gi1 protein alpha subunit; adenylate cyclase-inhibiting G alpha protein; Gi;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Antibody
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- Baculovirus-Insect cells
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mouse
- Wheat Germ
- GST
- His
- HIS
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- TwinStrep
- Involved Pathway
- Protein Function
- Interacting Protein
GNAI1 involved in several pathways and played different roles in them. We selected most pathways GNAI1 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | CALM2;P2RY1;FGF10;ID1;PDGFRA;LPAR3;FGF22;MRAS;ITGB3 |
| cGMP-PKG signaling pathway | Adcy4;MEF2B;GNAI2;MEF2C;GNA11;PRKCE;GNA12;PPP1CB;PPP3CA |
| cAMP signaling pathway | CAMK2D;GABBR1;PIK3CD;GIPR;PPP1CC;ACOX1;SLC9A1;HCN4;FXYD2 |
| Chemokine signaling pathway | GNG10;CXCR1;NFKBIB;GM10591;GRK7;CCR7;Ccl21c;STAT5B;GRK6 |
| Sphingolipid signaling pathway | TP53;MAPK13;RELA;PLD1;MAP2K1;PPP2R2A;PPP2R5D;PPP2R3A;SPHK1 |
| Adrenergic signaling in cardiomyocytes | PLCB4;MAPK12A;CACNG2;CACNB4A;PRKACAA;CALM2;ATF4;ADRB3A;CACNB4 |
| Axon guidance | TRPC3;SCN3B;IL17RD;CSF2;NRAS;TRPC5;SEMA3AB;SEMA6C;SDCBP |
| Tight junction | RHOAA;CLDN15LB;CLDNE;KRAS;MYLPFA;MPP5A;PPP2CB;LLGL1;ACTN3A |
| Gap junction | TUBA4L;GRB2B;PLCB3;GNA15.1;TUBA2;GNAI1;ADCY1B;TJP1;DRD2L |
| Platelet activation | MAPK13;PLA2G4C;ROCK1;PPP1CB;GNAI3;MYLK3;GUCY1B3;PRKCZ;PRKACB |
| Leukocyte transendothelial migration | ACTN1;ICAM1;Itgam&Itgb2;RAP1B;CDH5;THY1;CLDN2;ITGB2;MMP2 |
| Circadian entrainment | PER1;PRKCB;GNG13;CALM4;MAPK1;GRIA2;PLCB2;CAMK2B;KCNJ9 |
| Retrograde endocannabinoid signaling | GNG7;PRKACB;SLC17A7;GNAI2;GNB3;GNG2;GNAI3;PRKCG;GABRG1 |
| Glutamatergic synapse | GNG13;DLGAP1;PLA2G4D;SLC38A2;GRIN3A;GRIN3B;GRM3;SHANK2;PPP3CA |
| Cholinergic synapse | AKR1C1;GNAI2;KCNQ5;BCL2;PRKCG;CHRM5;PIK3R5;PIK3R2;PIK3CA |
| Serotonergic synapse | HTR4;GNG12;SLC18A2;GNAI1;GNAS;GNG13;CYP2D10;CYP2J6;GNAI2 |
| GABAergic synapse | GNAO1;SRC;GNB1;PLCL1;Adcy4;GABRA3;GNG2;GABRP;GABRQ |
| Dopaminergic synapse | PPP2R2B;AKT2;GNG5;PPP2R5E;GNG10;PRKACA;KCNJ9;PPP2R2D;CREB3L1 |
| Long-term depression | BRAF;PLCB1;GRIA1;GNAQ;GNAO1;KRAS;PRKG1;PLA2G4D;GNAI1 |
| Progesterone-mediated oocyte maturation | PIK3CG;MAPK10;HSP90AA1;CCNB3;CDC25A;INS1;ANAPC11;CPEB1;IGF1RB |
| Estrogen signaling pathway | PIK3CB;PRKACA;CREB3L3;NRAS;HSP90AB1;ITPR1;GNAI2;MMP9;PIK3R2 |
| Melanogenesis | KIT;GNAO1;Kitl;DVL1B;KITB;WNT5A;PLCB4;CALM;GNAS |
| Oxytocin signaling pathway | ITPR1;CALM2;CACNB4;PRKAB1;Adcy4;CALML5;MAPK1;PLA2G4C;ACTB |
| Regulation of lipolysis in adipocytes | IRS4;PTGER3;PTGS2;PIK3CB;IRS1;NPY1R;PRKACB;NPR1;PRKG1 |
| Renin secretion | CLCA1;CALM4;NPR1;PPP3CA;AGTR1B;PLCB2;AGTR1A;CALML5;PTGER4 |
| Gastric acid secretion | CAMK2G;MYLK2;GNAI1;CAMK2A;PRKACB;ATP4B;KCNJ1;MYLK3;CAMK2D |
| Parkinsons disease | PINK1;SNCAIP;SLC25A31;mt-Atp8;NDUFA11;ATP5G1;UQCRB;GPR37;SLC18A2 |
| Cocaine addiction | DRD2;GRIN3B;BDNF;GRIA2;SLC6A3;CREB3;PRKACA;DRD1;MAOB |
| Alcoholism | HIST3H2A;CALM2;DDC;PPP1CC;GNB1;GM14478;HIST1H2AE;GRIN3A;GRIN2C |
| Pertussis | ITGAM;C1S;C1QC;RHOA;CALM3;Il23a;C1R;IL1A;C4BPB |
| Chagas disease (American trypanosomiasis) | GNAQ;PPP2R1B;IRAK4;IL1B2;IFNB1;Ccl12;CALR;PPP2CB;MAP2K4 |
| Toxoplasmosis | LAMB1;HLA-DPB1;PDPK1;TGFB2;MAP2K3;IRAK1;MAPK9;CD40;MAPK11 |
| Pathways in cancer | CSF1R;CYCS;PAX8;LPAR5;FZD2;MAPK9;CASP9;PIK3R1;TGFB3 |
GNAI1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI1 itself. We selected most functions GNAI1 had, and list some proteins which have the same functions with GNAI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein beta/gamma-subunit complex binding | GNA15;GNAZ;GNA13B;GNA12A;GNA15.1;GNAIA;GNA12;GNAS;GNAO1 |
| G-protein coupled serotonin receptor binding | GNAI3;GNAZ;GNAIA;GNAI1;GNAO1B;GNAO1;GNAO1A |
| GDP binding | ARL2;RAB28;RAB2A;TRIM23;PIGC;IIGP1;RAB10;RAB35;RAB17 |
| GTP binding | ARHGAP5;RAB36;GNAI3;RAB11B;RAB7B;RAB6C;HRASA;NRAS;RAB27A |
| GTPase activating protein binding | PIN1;MEX3B;RGS14;GNAO1;TSC1;GNAI3;TUBB;PLCD1;GAPVD1 |
| GTPase activity | ARL4C;GNB5;RALAA;TUBA8L3;RHOB;MFN2;RAB6C;RAB40C;RAB34A |
| metal ion binding | ANKMY2;GLIS3;FCNA;THAP8;SP9;USP19;GLI3;DGKZ;PHOSPHO1 |
| protein binding | CD79A;SIN3A;TSC2;PEX26;SAP30;WDR48;SZT2;CD8A;EDNRA |
| signal transducer activity | OLFR493;TAAR14D;GRM6B;OLFCG2;TAAR12E;GPR158;TICAM1;GPR139;OLFCG3 |
GNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI1.
NUMA1; GPSM2; RGS17; GPSM3; RGS14; RANGAP1; MT1A; GNG2; Cbx1
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