Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

KCNH2

  • Official Full Name

    Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2

  • Overview

    This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
  • Synonyms

    KCNH2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1; potassium voltage-gated channel subfamily H member 2; ERG-1; H-ERG; hERG-1; eag homolog; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; ether-a-go-go-related potassium channel protein;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cavia porcellus (Guinea pig)
  • Human
  • Rat
  • Sus scrofa (Pig)
  • E.coli expression system
  • HEK293
  • Mammalian cell
  • Mammalian Cell
  • C
  • 10×His
  • eGFP
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNH2-5059HCL Recombinant Human KCNH2 293 Cell Lysate HEK293 N/A
Human KCNH2-15H Recombinant Human KCNH2-3C-eGFP Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), C-10×His-tagged Mammalian cell C-10×His M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005
Human KCNH2-0838H Recombinant Human KCNH2 Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), eGFP tagged Mammalian cell eGFP M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005
Rat KCNH2-3183R Recombinant Rat KCNH2 Protein Mammalian Cell His
Rat KCNH2-2839R-B Recombinant Rat KCNH2 Protein Pre-coupled Magnetic Beads HEK293
Rat KCNH2-2839R Recombinant Rat KCNH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cavia porcellus (Guinea pig) RFL1218CF Recombinant Full Length Guinea Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged E.coli expression system His Full Length (1-162)
Sus scrofa (Pig) RFL20356SF Recombinant Full Length Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged E.coli expression system His Full Length (1-97)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KCNH2 Related Articles

KCNH2 involved in several pathways and played different roles in them. We selected most pathways KCNH2 participated on our site, such as Neuronal System, Potassium Channels, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuronal SystemKCNS3A;KCNK13B;CHRNA2;CHRNA3;KCNC4;KCNA7;KCNA1;KCND2;BCHE
Potassium ChannelsDDX1;KCNJ14;KCNMA1;KCNH2;KCNK2B;KCNA10;KCNK2;KCNB2;KCNC1B
SIDS Susceptibility PathwaysCREM;EN1;TAC1;CC2D1A;CHRFAM7A;ASCL1;CTCF;PKNOX1;SP3
Voltage gated Potassium channelsKCNA5;KCNG3;KCNA10;KCNH2;KCNH2A;KCNG1;KCNC3A;KCNA6A;KCNC1B

KCNH2 has several biochemical functions, for example, C3HC4-type RING finger domain binding, delayed rectifier potassium channel activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH2 itself. We selected most functions KCNH2 had, and list some proteins which have the same functions with KCNH2. You can find most of the proteins on our site.

Function Related Protein
C3HC4-type RING finger domain bindingPINK1;HSPA1A;KCNH2;DNAJA1;HSPA1B;HSPA8
delayed rectifier potassium channel activityKCNV1;KCND1;KCNQ4;KCNC3A;KCNS3;KCNS3A;KCNC4;KCNA6A;KCNF1A
identical protein bindingMPZL2B;HACL1;FHOD1;AIRE;ALCAMA;LRRK1;COL7A1;NOXO1;PLEKHH2
inward rectifier potassium channel activityKCNJ2A;KCNJ1A.4;KCNH2;KCNJ1A.3;KCNJ6;KCNJ12;KCNJ1A.6;KCNJ14;KCNJ15
phosphorelay sensor kinase activityKCNH8;KCNH2;KCNH1;KCNH5A;CASS4;KCNH1A;KCNH5;KCNH1B
protein bindingTMEM182;NANOS2;INSIG2;TXNRD1;HAT1;TSPAN12;WDFY2;RSPH9;TREML1
protein homodimerization activityASNSD1;C9orf142;ADAM10;STUB1;PSPH;XCL1;GTF2A2;PDGFC;SYT16
scaffold protein bindingKRT8;NLGN1;PDE4D;NCK2;MAPK3;CRIPT;DSP;KRT18;IKBKB
ubiquitin protein ligase bindingLRPPRC;STX8;SPG20;MAGEA2;MC4R;CALR;TNFRSF1B;TP53;ATXN3
voltage-gated potassium channel activityKCNH8;KCNH1B;CNGA3;KCNS3B;KCNA6;KCNC1B;KCNA6A;KCNJ11;KCNH1A
contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationKCNH2;KCNE1;KCNE1L
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationKCNE2;KCNQ1;KCNH2

KCNH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH2.

CAV1; PASK; NDUFS6; ARHH; CDC73; GABARAP; MAP1LC3B

Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).
Wulff, H; Castle, NA; et al. Voltage-gated potassium channels as therapeutic targets. NATURE REVIEWS DRUG DISCOVERY 8:982-1001(2009).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All KCNH2 Products

Required fields are marked with *

My Review for All KCNH2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends