"Apamin" Related Products

Synthetic Apamin

Cat.No.: TOXPP-534S
Product Overview: This product is a SK channel blocker with the formula of C79H131N31O24S4.
Description: Apaminis a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamindoes not affect KCa3.1 channel activity. Apaminmost likely acts as a pore blocker such as Scyllatoxinor Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 2027.34 Da
Protein length: 18
AA Sequence: AA sequence: H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2
Disulfide Bonds: Cys1-Cys11; Cys3-Cys15
Purity: > 98 %
Reconstitution: Water or saline buffer
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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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