"µ-conotoxin-CnIIIC" Related Products

Synthetic µ-conotoxin-CnIIIC

Cat.No.: TOXPP-513S
Product Overview: This product is a selective blocker of Nav1.4 channels with the formula of C92H141N35O28S6.
Description: µ-conotoxin CnIIICis aconopeptidethat has been isolated from the venom of the marine cone snailConus consors. µ-conotoxin CnIIICexhibits a myorelaxing effect through specific blockade of the skeletal muscleNav1.4 channels(IC50= 1.4 nM). µ-conotoxin CnIIICalso blocksNav1.2 channels(1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIICalso blocks theα3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes. µ-conotoxin CnIIICcompletely inhibits twitch tension in isolated mouse hemidiaphragms (IC50= 150 nM).
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 2375.8 Da
Protein length: 22
AA Sequence: AA sequence: Pyr-Gly-Cys3-Cys4-Asn-Gly-Pro-Lys-Gly-Cys10-Ser-Ser-Lys-Trp-Cys15-Arg-Asp-His-Ala-Arg-Cys21-Cys22-NH2
Disulfide Bonds: Cys3-Cys15; Cys4-Cys21; Cys10-Cys22
Purity: > 97 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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