|Product Overview:||This product is a fluorescent Nav1.7 blocker with the formula of C168H250N46O41S8.|
|Description:||Cy5-ProTx-IIis a fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. The Cy5-ProTx-II version has potent Nav1.7 blocking activity. It was shown to fully block Nav1.7 at 100 nM concentration.|
|Form:||Dark lyophilized solid|
|Molecular Mass:||~4450 g/mol|
|AA Sequence:||AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
Disulfide Bonds: Cys2-Cys16; Cys9-Cys21; Cys15-Cys25
|Purity:||> 95 %|
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