"GaTx2" Related Products

Synthetic GaTx2

Cat.No.: TOXPP-566S
Product Overview: This product is a selective blocker of ClC2 (CLCN2) chloride channels with the formula of C125H199N39O47S6.
Description: GaTx2(gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus.GaTx2is the most potent peptide inhibitor ofClC-2 (CLCN2) chloride channelever described. Kdvalue is close to 20 pM.GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally,GaTx2is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3191.25 Da
Protein length: 29
AA Sequence: AA sequence: Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH
Disulfide Bonds: Cys3-Cys19; Cys6-Cys24; Cys10-Cys26
Purity: > 98 %
Reconstitution: Water or saline buffer

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.