"Huwentoxin-I" Related Products

Synthetic Huwentoxin-I

Cat.No.: TOXPP-563S
Product Overview: This product is a blocker of N-type Ca2+channel and TTX-S channels with the formula of C161H246N48O44S6.
Description: Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor oftetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50~ 50 nM) and N-type voltage-sensitive calcium channels (IC50~ 100 nM) in mammalian DRG, hippocampus and insect’s DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels. The selectivity ofHuwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA. Huwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED50~ 0.28 µg/kg), without side effects of the ones led by ω-conotoxin MVIIA.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3751.77 Da
Protein length: 33
AA Sequence: AA sequence: Ala-Cys2-Lys-Gly-Val-Phe-Asp-Ala-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Arg-Val-Cys22-Ser-Asp-Lys-His-Lys-Trp-Cys26-Lys-Trp-Lys-Leu-OH
Disulfide Bonds: Cys2-Cys17; Cys9-Cys22; Cys16-Cys29
Purity: > 97 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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