"Leiurotoxin-1 Dab7" Related Products

Synthetic Leiurotoxin-1 Dab7

Cat.No.: TOXPP-537S
Product Overview: This product is a SK2 channel blocker with the formula of C141H236N46O39S6.
Description: Leiuorotoxin-Dab7 (Lei-Dab7) is a mutated version of Leiurotoxin, a peptide identified from the venom of the scorpion Leiurus quinquestriatus hebraeus. The Dab amino acid in position 7 confers to this compound a high selectivity for SK2 channels among other channels. Lei-Dab7 exhibits > 200 fold selectivity for SK2 over SK1, SK3, IK, Kv and Kir channels. The IC50 for SK2 is about 3 nM.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3392.12 Da
Protein length: 31
AA Sequence: AA sequence: Ala-Phe-Cys3-Asn-Leu-Arg-Dab-Cys8-Gln-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Asp-Lys-Cys26-Glu-Cys28-Val-Lys-His-NH2
Disulfide Bonds: Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
Purity: > 95%
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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