"Mambalgin-1" Related Products

Synthetic Mambalgin-1

Cat.No.: TOXPP-579S
Product Overview: This product is a ASIC1a & 1b channel blocker with the formula of C272H429N85O84S10.
Description: Mambalgin-1 was initially isolated by Sylvie Diochot and collaborators from the venom of the black mamba (Dendroaspis polylepis polylepis). Mambalgin-1 is a potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets. Mambalgin-1 rapidly and reversibly inhibits recombinant homomeric ASIC1a (IC50=55 nM) and heteromeric ASIC1a+ASIC2a (IC50=246 nM) or ASIC1a+ASIC2b channels (IC50=61 nM) but also human channels hASIC1b (IC50=192 nM) and  hASIC1a+hASIC1b (IC50=72nM).
Source: synthetic
Species: synthetic
Form: White lyophilized solid
Molecular Mass: 6554.59 Da
Protein length: 57
Disulfide Bonds: Cys3-Cys19; Cys12-Cys37; Cys41-Cys49; Cys50-Cys55
Purity: > 98 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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