"Margatoxin" Related Products

Synthetic Margatoxin

Cat.No.: TOXPP-546S
Product Overview: This product is a Kv1.3 selective blocker with the formula of C178H286N52O50S7.
Description: Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent thanCharybdotoxin) and irreversibly inhibits the proliferation responseof human T-cellsat 20 µM concentration.Margatoxinis known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50around 1 nM). Margatoxinwas also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4179.03 Da
Protein length: 39
AA Sequence: AA sequence: Thr-Ile-Ile-Asn-Val-Lys-Cys7-Thr-Ser-Pro-Lys-Gln-Cys13-Leu-Pro-Pro-Cys17-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys29-Met-Asn-Gly-Lys-Cys34-Lys-Cys36-Tyr-Pro-His-OH
Disulfide Bonds: Cys7-Cys29; Cys13-Cys34; Cys17-Cys36
Purity: > 97 %
Reconstitution: Water or saline buffer
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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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