"Phrixotoxin-3" Related Products

Synthetic Phrixotoxin-3

Cat.No.: TOXPP-511S
Product Overview: This product is a selective blocker of Nav1.2 with the formula of C171H245N53O47S6.
Description: Phrixotoxin-3(PaurTx3 or Beta-theraphotoxin-Ps1a) is a valuable pharmacological tool to study voltage-gated sodium channels. Phrixotoxin-3, originally issued from the venom of the tarantula phrixotrichus auratus, has been shown to inhibitNav1.1,Nav1.2,Nav1.3,Nav1.4 and Nav1.5 with respective IC50 values of 610 nM, 0.6 nM, 42 nM, 288 nM and 72 nM. It is thus considered as one of the most potent and almost selective modulator of Nav1.2.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4059.9 Da
Protein length: 34
AA Sequence: AA sequence: Asp-Cys2-Leu-Gly-Phe-Leu-Trp-Lys-Cys9-Asn-Pro-Ser-Asn-Asp-Lys-Cys16-Cys17-Arg-Pro-Asn-Leu-Val-Cys23-Ser-Arg-Lys-Asp-Lys-Trp-Cys30-Lys-Tyr-Gln-Ile-OH
Disulfide Bonds: Cys2-Cys17; Cys9-Cys23; Cys16-Cys30
Purity: > 97 %
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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