"ProTx-III" Related Products

Synthetic ProTx-III

Cat.No.: TOXPP-525S
Product Overview: This product is a new selective Nav1.7 blocker with the formula of C162H246N52O43S6.
Description: ProTx-III (µ-TRTX-Tp1a; belongs to NaSpTx family 1) has been isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens at the University of Queensland (Australia). ProTx-III has been described to be a selective inhibitor of Nav1.7 with an IC50 value around 2 nM. The synthetic version of Tp1a produced by Creative BioMart yields similar results in terms of Nav1.7 inhibition. Queensland scientists have described that ProTx-III induces no significant changes in the voltage dependence of activation or steady-state inactivation of Nav1.7. ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors. ProTx-III demonstrates analgesic propertiesin vivowhen injected intraplantary in mice prior treatment with OD1, an activator of Nav1.7, which induces spontaneous pain.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 3802.47 Da
Protein length: 33
AA Sequence: AA sequence: Asp-Cys2-Leu-Lys-Phe-Gly-Trp-Lys-Cys9-Asn-Pro-Arg-Asn-Asp-Lys-Cys16-Cys17-Ser-Gly-Leu-Lys-Cys22-Gly-Ser-Asn-His-Asn-Trp-Cys29-Lys-Leu-His-Ile-NH2
Disulfide Bonds: Cys2-Cys17; Cys9-Cys22; Cys16-Cys29
Reconstitution: Water or saline buffer, 5 mg/mL maximum (recommendation)

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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