|Product Overview:||This product is a new selective Nav1.7 blocker with the formula of C162H246N52O43S6.|
|Description:||ProTx-III (µ-TRTX-Tp1a; belongs to NaSpTx family 1) has been isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens at the University of Queensland (Australia). ProTx-III has been described to be a selective inhibitor of Nav1.7 with an IC50 value around 2 nM. The synthetic version of Tp1a produced by Creative BioMart yields similar results in terms of Nav1.7 inhibition. Queensland scientists have described that ProTx-III induces no significant changes in the voltage dependence of activation or steady-state inactivation of Nav1.7. ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors. ProTx-III demonstrates analgesic propertiesin vivowhen injected intraplantary in mice prior treatment with OD1, an activator of Nav1.7, which induces spontaneous pain.|
|Form:||White lyophilized solid|
|Molecular Mass:||3802.47 Da|
|AA Sequence:||AA sequence: Asp-Cys2-Leu-Lys-Phe-Gly-Trp-Lys-Cys9-Asn-Pro-Arg-Asn-Asp-Lys-Cys16-Cys17-Ser-Gly-Leu-Lys-Cys22-Gly-Ser-Asn-His-Asn-Trp-Cys29-Lys-Leu-His-Ile-NH2
Disulfide Bonds: Cys2-Cys17; Cys9-Cys22; Cys16-Cys29
|Reconstitution:||Water or saline buffer, 5 mg/mL maximum (recommendation)|
Price does not include shipping and packaging costs.Request quote for final price.