"Psalmotoxin-1 / PcTx1" Related Products

Synthetic Psalmotoxin-1 / PcTx1

Cat.No.: TOXPP-580S
Product Overview: This product is a ASIC1a selective blocker with the formula of C200H312N62O57S6.
Description: Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50= 1 nM) and selectively theH+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible.PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 4690.82 Da
Protein length: 40
AA Sequence: AA sequence: Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr-OH
Disulfide Bonds: Cys3-Cys18; Cys10-Cys23; Cys17-Cys33
Purity: > 98%
Reconstitution: Water or saline buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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