"Rho-Conotoxin-TIA" Related Products

Synthetic Rho-Conotoxin-TIA

Cat.No.: TOXPP-584S
Product Overview: This product is a blocker of α1-adreno receptor with the formula of C105H160N36O21S4.
Description: Rho-conotoxin TIA is acono peptide that has been isolated from the venom of the fish-hunting marine cone snail onus tulipa. ho-conotoxin TIA is a selective antagonist of α1-adreno receptor (α1A-, α1B– and α1D-AR). It acts non-competitively onto α1B-adreno receptor but competitively on α1A-adreno receptor and α1D-adreno receptor. The most important residue for activity is Arg4. Rho-conotoxin TIA is 10-fold selective for human α1B-adreno receptor over α1A-adreno receptor and α1D-adreno receptor. The IC50 values for Rho-conotoxin TIA for inhibition of 125I-BE were 18 nM for human α1A-AR, 2 nM for α1B-AR and 25 nM for α1D-AR.
Source: Synthetic
Species: Synthetic
Form: White lyophilized solid
Molecular Mass: 2390.90Da
Protein length: 19
AA Sequence: AA sequence: Phe-Asn-Trp-Arg-Cys5-Cys6-Leu-Ile-Pro-Ala-Cys11-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys19-NH2
Disulfide Bonds: Cys5-Cys11; Cys6-Cys19
Purity: > 95 %
Reconstitution: Aqueous buffer

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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