|Product Overview:||This product is a blocker of muscle nAChRs with the formula of C133H185N37O32S2.|
|Description:||Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I (GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.|
|Form:||White lyophilized solid|
|Molecular Mass:||2878.27 Da|
|AA Sequence:||AA sequence: FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His-Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH
Disulfide Bonds: Cys9-Cys13
|Reconstitution:||Water or saline buffer|
Price does not include shipping and packaging costs.Request quote for final price.