Human tissue plasminogen activator


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Cat#:  THP-0011
Product Name:  Human tissue plasminogen activator
Description:  Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. It is the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
Formula:  C2569H3928N746O781S40
Sequences:  SYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
Species:  Human
Source:  CHO
CAS No. :  81669-57-0
Molecular Weight:  59042.3 Da
Synonyms:  Anisoylated plasminogen streptokinase activator complex; APSAC
Drug name:  Anistreplase
Applications:  For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction.
Examples of Clinical Use:  Acute pulmonary emboli, intracoronary emboli and myocardial infarction.
Pharmacodynamics :  The product cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Mechanism of action:  Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.
Affected organisms:  Humans and other mammals
Targets:  Target 1. Plasminogen; Target 2. Fibrinogen alpha chain; Target 3. Urokinase plasminogen activator surface receptor; Target 4. Plasminogen activator inhibitor 1
Catalog# Product Name Inquiry
THP-0010 Human tissue plasminogen activator Inquiry
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THP-0014 Direct inhibitor of human thrombin Inquiry
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