IFN-Omega 1 (IFNW1)


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Cat#:  THP-0253
Product Name:  IFN-Omega 1 (IFNW1)
Description:  IFN-Omega 1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.9kDa. The IFN-Omega 1 is purified by proprietary chromatographic techniques.
Introduction:  IFN-Omega 1 is a type I IFN, that can be induced by virus-infected leukocytes. Type I IFN family members, which include IFN-alpha, IFN-beta, and IFN-omega, signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities. IFNW1 exhibits about 75% sequence homology with IFN-a, and contains 2 conserved disulfide bonds, which are essential for full biological activity.
Sequences:  MCDLPQNHGL LSRNTLVLLH QMRRISPFLC LKDRRDFRFP QEMVKGSQLQ KAHVMSVLHE MLQQIFSLFH TERSSAAWNM TLLDQLHTGL HQQLQHLETC LLQVVGEGES AGAISSPALT LRRYFQGIRV YLKEKKYSDC AWEVVRMEIM KSLFLSTNMQ ERLRSKDRDL GSS.
Species:  Human
Source:  E. coli
Molecular Weight:  19.9kDa
Synonyms:  IFN omega-1; IFN alpha-II-1; IFNW1;
Biological Activity:  The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 100,000,000 units/mg.
Purity:  >95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation:  Sterile Filtered White lyophilized (freeze-dried) powder. Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
Storage:  Lyophilized IFNW1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution IFNW1 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution:  It is recommended to reconstitute the lyophilized IFNW1 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Applications:  Signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities
Examples of Clinical Use:  Having antiviral and antiproliferative activities.
Affected organisms:  Humans
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