Growth Hormone-Releasing Hormone (GHRH)


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Cat#:  THP-0280
Product Name:  Growth Hormone-Releasing Hormone (GHRH)
Description:  Recombinant Human Growth Hormone-Releasing Hormone (GHRH) protein (Tyr32-Leu75) was expressed with the Fc region of human IgG1 at the N-terminus.
Introduction:  The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may play an important role in inhibiting seizures by activating GABAARs. GHRH is produced by tumor cells, acts in an autocrine/paracrine manner, and requires the presence of GHRH receptor (GHRH-R) on the tumor cells to exert its effects. GHRH activity can be effectively blocked by synthetic antagonists of its receptor and hence, the expression of GHRH-R by tumor cells could serve as a predictor of response to GHRH-R antagonist therapy. The neurovascular protective effect of GHRH analogs during the early stage of diabetic retinopathy through their antioxidant and anti-inflammatory properties. GHRH antagonists can be a therapeutic option for thyroid cancer patients.
Species:  Human
Source:  HEK293 Cells
Molecular Weight:  33.5 kDa.
Synonyms:  GHRF Protein, Human; GRF Protein, Human; INN Protein, Human;
Purity:  > 85 % as determined by SDS-PAGE.
Formulation:  Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Storage:  Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level:  < 1.0 EU per μg protein as determined by the LAL method.
Applications:  GHRH may play an important role in inhibiting seizures by activating GABAARs. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. The neurovascular protective effect of GHRH analogs during the early stage of diabetic retinopathy through their antioxidant and anti-inflammatory properties. GHRH antagonists can be a therapeutic option for thyroid cancer patients.
Examples of Clinical Use:  Playing an important role in infertility, seizures, and diabet.
Affected organisms:  Humans
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For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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