Recombinant human basic fibroblast growth factor


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Cat#:  THP-0292
Product Name:  Recombinant human basic fibroblast growth factor
Description:  Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in Japan as a topical spray for the treatment of skin ulcers. It is also currently in preregistration for the treatment of periodontitis. As a recombinant form of bFGF, trafermin is a potent agonist of the FGFR1, FGFR2, FGFR3, and FGFR4. The drug has been marketed in Japan since June 2001.
Formula:  C764H1201N217O219S6
Species:  Human
CAS No. :  131094-16-1
Molecular Weight:  17.122 kDa
Synonyms:  Recombinant human basic fibroblast growth factor; rhbFGF; Trafermin
Drug name:  Trafermin
Applications:  Investigated for use/treatment in coronary artery disease, peripheral vascular disease, periodontal disease, bone fractures, entero-related fistulae, and diabetic foot ulcers.
Examples of Clinical Use:  Periodontitis; Alveolar Bone Losses / Periodontal Attachment Loss / Periodontitis; Diabetic Foot Ulcer of Neuropathic Origin; Periodontitis; Tympanic Membrane Perforation
Mechanism of action:  Trafermin, or basic fibroblast growth factor 2 (bFGF) is a recombinant human growth factor used to stimulate angiogenesis and keratinization in wound healing. It stimulates migration of monocytes, neutrophils, macrophages, fibroblasts and also assists in creation of granulation tissue (the tissue that replaces fibrin clots in healing wounds).
Catalog# Product Name Inquiry
THP-0290 Recombinant fibroblast growth factor-1 Inquiry
THP-0293 Complement activator blocker-2 Inquiry


For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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