JEM: Prevent Exhaustion in Immune Cells Boosts Immunotherapy

If you are an immune cell ready to fight cancer, you’d better eat some breakfast. Because the tumor microenvironment is a harsh place, and tumor cells are always ready to make you exhausted.   Improvement of highly specific immune fighter in vivo: The ability of T cells to attack tumors has achieved clinically significant advances in tumor immunotherapy. However, this method is only effective in 10-30% of patients. One reason…

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Nature Communication: Proteins that Make Difference between Cancerous and Healthy Cells Found

A recent study published in Nature Communication reveals how cancerous cells differ from healthy ones, which paves way for the development of novel strategies for the therapeutic intervention for difficult-to-treat cancers in the future.   An international research team discovered a “stop sign”- a mutated protein called PIP-stop, which is overused by tumor cells and can effectively prevent healthy cells from classifying in the way they are designed to.  …

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Recent Research Progress in Heart Disease (II)

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(Continued)   4. Nat Commun: Latest research finds the key protein mechanism, which regulates heart and muscle   David Giganti et al, Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity, Nature Communications (2018). DOI: 10.1038/s41467-017-02528-7     Scientists from CNIC and Columbia University have identified a key protein regulatory mechanism that regulates skeletal muscle and heart muscle function. Research results have recently been published in…

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Recent Research Progress in Heart Disease (I)

What we are bringing to you this time is recent advances in heart disease research and we hope it will be useful to you.   1. NEJM: Influenza increases the probability of heart attack by 6 times!   Jeffrey C. Kwong et al.Acute myocardial infarction after laboratory-confirmed influenza.N Engl J Med 2018; 378:345-353 DOI: 10.1056/NEJMoa1702090 infection     According to a recent study completed by ICRS and PHO researchers, the…

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Cell: TBK1 Is the Blockage to Weight Loss

Highlights TBK1 operates at the intersection of energy expenditure and inflammation TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK   Do you ever wonder why fat body burns even fewer calories, or why dieting for weight loss always has bottlenecks? That’s because in both cases, our body tries to defend…

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Science: How Does the “Clock” Protein Work?

As we all know that the human body can function adaptively as the day and night change. And according to a new research from the Perelman School of Medicine at the University of Pennsylvania, a key protein called Rev-erb coordinates the ebb and flow of gene expression by tightening and loosening loops in chromosomes.   For the past 15 years, Mitchell A. Lazar et al. have been dedicated to revealing…

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