Alzheimer’s Disease and Insulin—Is There Any Connection?

Johnson & Johnson recently announced that the company has stopped a clinical trial of a new Alzheimer’s disease drug due to certain safety issues. This is another failed clinical trial following the announcement of several large clinical trials that have no effect in treating Alzheimer’s disease. More and more failure cases tell us that we need to stop and think about how we could find the cause of Alzheimer’s disease….

Read More >>

Nat Med: Key Factors Determining the Anticancer Effect of Immunological Checkpoint Therapy

Stimulatory dendritic cells (SDCs) play a key role in stimulating cytotoxic T lymphocytes and promoting immune responses against cancer. Studying the mechanisms that regulate the abundance of SDCs in the tumor microenvironment (TME) will provide new therapeutic strategies.     Rencently, researchers from the University of California, San Francisco, studied the abundance in human melanoma and the influencing factors of SDC, and found it was associated with intratumoral expression of…

Read More >>

Immunity: Why Can’t HIV Be Cured? Scientists Find the Key Mechanism!

Due to the rapid development of antiretroviral therapy (ART), HIV patients can live longer than before. But even if it is a very effective long-term ART, the HIV virus remains stubbornly incurable, so patients need medication for life. Scientists have been convinced that this is because the HIV virus has created a stubborn virus-infected cell nest that allows HIV to survive indefinitely. A recent study done by researchers at Brigham…

Read More >>

PNAS: A Key Switch in Biological Clocks Found

Multipoint phosphorylation of the PERIOD 2 (PER2) protein is a critical step in determining the mammalian clock cycle. Previous studies have suggested that the phosphorylation of PER2 by casein kinase 1 (CK1) requires the initiation of an undiscovered protein kinase. CK1 is an essential circulatory protein that is highly conserved from algae to humans. These phosphorylation processes stabilize the PER2 and delay its degradation to extend the circadian clock cycle….

Read More >>

Two Articles Revealed a Specific Gene That Makes the Human Brain Big—NOTCH2NL

Over the past 3 million years, the evolution of larger brains has played an important role in our ability to think, solve problems, and develop cultures. However, it has always been a mystery for us to become genetic changes in the human brain. In two papers published in Cell, two groups of researchers identified a gene family, NOTCH2NL, which appears to play an important role in the human-specific cortical development…

Read More >>

Ways to Promote Durable Weight Loss in Obese Patients Found

Recently, in a study published in Nature Medicine, researchers from Charite Medical College in Berlin successfully treated obese patients due to hereditary defects. The new drugs developed by the researchers not only benefit patients, but also help them understand the basic signal pathways that regulate the satiety of this new drug.   Gene mutations that encode leptin receptors induce individuals to become extremely hungry during the first few months of…

Read More >>