New Drug Resistance Mechanism Found Through Persevere Research of Prostate Cancer

prostate cancer

Most tumor growing can stop after long-time medicine intake, and even it can become smaller or finally disappear. But what made the doctors struggling was that a few months later cancer cells gradually developed resistance and the tumor was once again deteriorating and menacing. Without good second-line anti-cancer drugs, physicians and patients really can do nothing. However, with the persevering efforts of scientists, we have the opportunity to gain the…

Read More >>

Interpretation of the Recent PD-1 Research Progress (Part II)

Immunotherapy with oncolytic virus combined with PD-1 inhibitor

Continued   6. Nature’s New Discovery: Another Unidentified Anti-cancer Approach of PD-1 / PD-L1 Antibodies doi: 10.1038/nature22396.   On May 17, Nature published an online article titled “PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity”, revealing the immune checkpoint inhibitors represented by the PD-1 / PD-L1 antibody can fight cancer in a completely different way.   Dr. Irving Weissman, a professor of pathology and developmental biology at Stanford…

Read More >>

Interpretation of the Recent PD-1 Research Progress

PD-1 (programmed cell death protein 1), the programmed death receptor 1, is an important immunosuppressive molecule. Immunomodulation which targets PD-1 is of great importance to anti-tumor, anti-infective, anti-autoimmune diseases, and organ transplant survival. In recent years, scientists have made a number of achievements in the field of PD-1 research. We will share the relevant research here.   1.Science: Scientists confirm that intestinal microbes affect PD-1 / L1 antibody treatment for…

Read More >>

Highlights of the Journal Cell for Oct, 2017 (III)

Cell

(Continued)     9. Draw a four-dimensional map of the self-folding of the human genome   Suhas S.P. Rao, Su-Chen Huang, Brian Glenn St Hilaire et al. Cohesin Loss Eliminates All Loop Domains. Cell, 5 October 2017, 171(2):305–320, doi:10.1016/j.cell.2017.09.026   In a new study, researchers from institutions such as Baylor College of Medicine, Rice University, Stanford University and Broad Institute, constructed the high-resolution four-dimensional map of the human genome fold for…

Read More >>

Highlights of the Journal Cell for Oct, 2017 (II)

(Continued)   5. On average, one to ten mutations are sufficient to promote cancer   Iñigo Martincorena, Keiran M. Raine, Moritz Gerstung et al. Universal Patterns of Selection in Cancer and Somatic Tissues. Cell, Published online: October 19, 2017, doi:10.1016/j.cell.2017.09.042     In a study of more than 7,500 tumors of 29 cancer types, researchers from the Wellcome Trust Sanger Institute, the European Bioinformatics Institute, and the Francis-Crick Institute unbiased evaluated…

Read More >>

Highlights of the Journal Cell for Oct, 2017 (I)

Cell

There are lots of great articles published on Cell in October, let’s share some highlights for you.    1. New discovery on cancer metabolic which challenge the view of nearly 100 years   Brandon Faubert, Kevin Y. Li, Ling Cai et al. Lactate Metabolism in Human Lung Tumors. Cell, 5 October 2017, 171(2):358–371, doi:10.1016/j.cell.2017.09.019   In this new study, researchers from the Children’s Medical Center (CRI) at the University of Texas…

Read More >>