Bone Morphogenetic Protein-13 (BMP-13)


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Cat#:  THP-0254
Product Name:  Bone Morphogenetic Protein-13 (BMP-13)
Description:  This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Introduction:  BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains.
Sequences:  TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
Species:  Human
Source:  E. coli
Molecular Weight:  27.0 kDa
Synonyms:  Bone Morphogenetic Protein-13; GDF-6; Cartilage-Derived Morphogenetic Protein-2 (CDMP-2);
Biological Activity:  The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.
Purity:  ≥ 95% by SDS-PAGE gel and HPLC analyses.
Applications:  Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects.
Examples of Clinical Use:  Augmenting periosteal repair of osteochondral defects.
Affected organisms:  Humans
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