Recently, researchers from Ghent University Hospital in Belgium published an article entitled “A human immune dysfunction syndrome characterized by severe hyperinflammation with a homozygous nonsense roquin-1 mutation” in Nature Communications. By studying a case of the hyperinflammatory syndrome with a homozygous nonsense mutation in Roquin-1, they discovered the mechanism of human immune dysregulation triggered by mutations in Roquin-1 protein, which may provide a new approach for the diagnosis and treatment…
Month: December 2019
Protein Scaffolds Found to Play a Key Role in Repairing DNA Breaks
Recently, researchers from the University of Copenhagen in Denmark have discovered how certain types of proteins keep damaged DNA stable, thereby preserving its function and integrity. The new findings also explain why people with congenital or acquired defects in certain proteins cannot keep their DNA stable and develop diseases such as cancer. The results were recently published in Nature under the title “Stabilization of Chromatin Topology safeguards genome integrity”. …