IFITM5 Mutation Causes Abnormal Differentiation of Bone Marrow Cells, Leading To V-Type Osteogenesis Imperfect

In a new study, researchers from research institutions such as Baylor School of Medicine revealed the molecular events that lead to osteogenesis imperfecta type V. This discovery provides new possibilities for designing treatments for this incurable disease. The relevant research results were published online in the Journal of Clinical Investigation, under the title “The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect”.  …

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MYCT1 Plays a Crucial Role in Self-Renewal of Human Hematopoietic Stem Cells

In a new study, researchers from the University of California, Los Angeles discovered a protein called MYCT1 that plays a crucial role in regulating self-renewal by helping human hematopoietic stem cells (HSCs) perceive and interpret signals from their environment. This discovery brings scientists one step closer to the method of amplifying hematopoietic stem cells in laboratory culture dishes, making it easier to obtain life-saving hematopoietic stem cell transplants and improving…

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Single Infusion of Long-Lived Multifunctional T Cells with IL4 Mutations Can Provide Lasting Relief for Asthma

In a new study, researchers from Tsinghua University in China found that genetically modified long-lived multifunctional T cells can inhibit the symptoms and signs of allergic asthma in mice for up to a year. Specifically, they genetically modified CAR-T cells to reduce the function of interleukins associated with type 2 high characteristic asthma. The relevant research results were published in the Nature Immunology journal, titled “A single infusion of engineered…

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MSD PD-1 Inhibitor Approved By FDA for First-Line Treatment of Advanced Cancer

Keytruda is a PD-1 inhibitor developed by Merck, which can block the interaction between PD-1 and its ligands PD-L1 and PD-L2, release immune suppression mediated by the PD-1 signaling pathway, activate T lymphocytes that may affect tumor cells and healthy cells, and enhance the human immune system’s ability to detect and eliminate cancer cells.   Since obtaining FDA approval for the treatment of advanced melanoma for the first time in…

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A Novel Therapy for Alzheimer’s disease Targeting Neuronal Calcium Homeostasis

A new study published in the journal Science has brought us a new approach to the treatment of Alzheimer’s disease (AD). Unlike many previous approaches to new drug development, this therapy does not target the key pathological proteins of Alzheimer’s disease, beta-amyloid (Aβ) or tau protein, but rather targets the more fundamental neuronal calcium homeostasis.   Calcium ion disorders play an important pathological role in various types of dementia, including…

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Liver ACOX1 Regulates Circulating Lipid Levels and Promotes Metabolic Health through Fat Remodeling

Obesity is a serious public health problem, which is related to a wide range of complications, including type 2 diabetes, cardiovascular disease, and liver steatosis. Dysfunction of lipid metabolism is a hallmark of obesity, related to the pathogenesis of these comorbidities. The imbalance between lipid synthesis and degradation leads to the accumulation of excess fat in adipose tissue and other organs.   Brown adipose tissue (BAT) or related beige adipose…

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CRL3 May Have the Potential to Lower Blood Sugar Levels in the Body

Cullin RING E3 ligase (CRL) has become a key regulator of disease modification pathways and therapeutic targets. CRL (CRL3) containing Cullin 3 (Cul3) is involved in regulating liver insulin and oxidative stress signaling. However, the function of CRL3 in liver pathophysiology is currently unclear.   Recently, a research report titled “Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance” was published in…

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Commonly Used Cholesterol Lowering Drugs, Statins, Can Prevent Cancer

Researchers from Harvard Medical School and Massachusetts General Hospital published a research paper in the journal Nature Communications titled: Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression.   This study suggests that commonly used cholesterol-lowering drugs such as statins can prevent the progression of chronic inflammation to cancer by blocking the expression of interleukin-33 (IL-33). Our Related Proteins Cat. No. Product Name Species Source Tag IL33-122H…

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A New Strategy For Tumor Growth Inhibition: BCL9/BCL9L Targeted Therapy And cDC1 Activation

Zhu Di and Wang Mingwei from Fudan University jointly published a research paper titled “Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration” in Signal Transmission and Targeted Therapy. This study indicates that targeting BCL9/BCL9L enhances antigen presentation by stimulating cDC1 activation and infiltration into tumors. Knockout mice with novel inhibitors hsBCL9z96 or BCL9/BCL9L can significantly delay tumor growth and promote anti-tumor…

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Targeting SOX13 to Overcome Iron Death Resistance in Gastric Cancer

Gastric cancer (GC) is the fifth most common cancer and the fourth leading cause of cancer-related deaths in the world. Despite significant progress in gastric cancer management, the prognosis of patients with advanced gastric cancer remains poor. Cisplatin-based chemotherapy is still the first-line adjuvant or neoadjuvant treatment for advanced gastric cancer, but understanding chemotherapy resistance remains a barrier to clinical efficacy. Cancer immunotherapy, including immune checkpoint inhibitors, has become an…

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