The development of normal mammals occurs in a hydrogen-peroxide environment, and the adaptive response to hydrogen peroxide is considered a landmark event for embryo survival in hypoxic fallopian tubes and intrauterine environments, thus playing a crucial role in mammalian evolution. Due to the gene deletion of hypoxia-inducible factor (HIF) (oxygen-sensitive transcription factor), the response to physO2 is insufficient, resulting in embryo loss during implantation or severe developmental defects shortly after…