Recently, the Li Zigang/Yin Feng research group at the Shenzhen Graduate School of Peking University published a research paper titled “Targeted biomolecule regulation platform: a Split and Mix PROTAC approach” in the Journal of the American Chemical Society, reporting peptide self-assembly formed Split and Mix PROTAC (SM PROTAC), which achieved significant degradation effects on multiple targets, such as ERα, EGFR, MEK1/2, BRD2/4, CDK4/6, AR, BCR-ABL, etc. Targeted protein degradation…
bioengineering
Error-correcting Reverse Transcriptase: Increase the Precision of Transcriptomics Methods with Proofreading Function
Ellefson et al. construct a reverse transcriptase using in vitro directed evolution and protein engineering from a prokaryotic DNA polymerase. This reverse transcriptase shows increased fidelity as compared to natural reverse transcriptases and increases the precision of transcriptomics methods. Ellefson et al. published their results in Science Magazine (Science 24 Jun 2016: Vol. 352, Issue 6293, pp. 1590-1593 DOI: 10.1126/science.aaf5409). The article is followed: The molecular basis for life rests on the information flow…
Do you regard GMO-labels as negative warnings?
In the last two posts we have talked about bioengineering. I still want to lay my today’s topic on GMO. First a question, do you regard GMO-labels as negative warnings? A recent new study reveals that most of the people don’t regard GMO labeling as warning meanings and will not be scared away just by the labels. This study was released right after the U.S. House passed a bill that…
How do you think about bioengineering?
Bioengineering has always been discussed in the community. But for the esoteric knowledge of biology is poorly understood, it is often difficult to understand genetically modified products. According to a survey, only about 37% of Americans believe genetically modified foods are safe, and the scientific community in the United States scientists that believe GM foods are safe accounted for 88%. Recently, a company has developed a kind of flower that…
How far away is transgenic animal food from us?
According to the US “WIRED” magazine’s report, for a long time our human beings have almost transformed all of the plants and animals that provide us with food with traditional breeding methods. While the practice by using genetic engineering to make gene migration between different living organisms mutual implant makes people doubt about the future. This, however, is what happened in France two weeks ago: the offspring of lamb that…