Skin cancer is the most common cancer in the United States, with about 5 million cases every year. Melanoma is less common than other types of skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), but it causes most of the death of skin cancer. The risk of melanoma is related to environmental factors, such as ultraviolet radiation (UVR) and genetic background. It is noteworthy that…
AMPK
Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis
Leukemia is a highly aggressive hematological malignancy characterized by extensive molecular changes that affect clinical outcomes and provide potential drug development targets. However, the emergence of chemotherapy resistance obviously hinders the effect of chemotherapy and indicates a poor prognosis. About 15% – 30% of leukemia patients are resistant to chemotherapy, and 60% – 80% of patients with complete remission inevitably relapse and succumb to the disease. Therefore, it is very…