Highlights TBK1 operates at the intersection of energy expenditure and inflammation TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK Do you ever wonder why fat body burns even fewer calories, or why dieting for weight loss always has bottlenecks? That’s because in both cases, our body tries to defend…
Body Weight
Body Weight, Appetite and Lipocalin
Body weight is determined by energy balance. When the energy intake equals energy expenditure, the body weight remains unchanged. On the other hand, the body weight grow when the energy surplus. Energy balance is critical for survival and health, and control of food intake is an integral part of this process. Excess energy intake has become a scapegoat for the obesity epidemic in developed countries. While it is responsible in…