The correct positioning of membrane proteins on the corresponding organelles is important for maintaining the specific “identity” and physiological functions of the organelles. The correct positioning of membrane proteins relies on precise protein sorting pathways and requires corresponding mechanisms on organelles to eliminate mislocated proteins. For example, the AAA-ATPase Msp1 of the outer mitochondrial membrane can remove the protein that is incorrectly located on the outer mitochondrial membrane. However, what…